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Table 1.

Rescue of the placental phenotype in Sox2Cre transgene-mediated recombination

Genotype of live born pups
Map2k1+/+; Tg+/+Map2k1+/Δ; Tg+/+Map2k1floxed/Δ; Tg+/+Map2k1+/floxed; Tg+/+Map2k1+/+; Tg+/Sox2CreMap2k1+/Δ; Tg+/Sox2CreMap2k1Δ/Δ; Tg+/Sox2Cre
Number of pups 
% obtained 15% 20% 10% 10% 15% 15% 15% 
% expected 12.5% 12.5% 12.5% 12.5% 12.5% 25% 12.5% 
Genotype of live born pups
Map2k1+/+; Tg+/+Map2k1+/Δ; Tg+/+Map2k1floxed/Δ; Tg+/+Map2k1+/floxed; Tg+/+Map2k1+/+; Tg+/Sox2CreMap2k1+/Δ; Tg+/Sox2CreMap2k1Δ/Δ; Tg+/Sox2Cre
Number of pups 
% obtained 15% 20% 10% 10% 15% 15% 15% 
% expected 12.5% 12.5% 12.5% 12.5% 12.5% 25% 12.5% 

Male Map2k1+/Δ;Tg+/Sox2Crewere crossed with female Map2k1+/floxed

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