Phenotypic comparison of dig-1 alleles
| dig-1 allele . | PVQ soma . | PVQ axon . | Amphid neurons . | AVK soma . | AVK axon . | Gonad . | Molecular lesion . |
|---|---|---|---|---|---|---|---|
| Wild type | − | − | − | − | − | − | − |
| ky188 | ++ | +++ | ++ | ++ | ++ | + | ? |
| ky199 | +++ | + | +++ | ++++ | + | ++++ | 11 bp deletion at codon 2083, out of frame |
| ky201 | +++ | + | +++ | ++++ | +++ | +++ | ? |
| n1321 | ++ | − | ++++ | +++ | + | ++++* | Stop codon at base 8367 |
| n1480 | +++ | − | ++ | ++++ | + | +++* | insertion/deletion in repetitive region* |
| nu336 | +++† | − | +++ | +++ | + | +* | Missense in repetitive region* |
| nu52 | ++ | − | ++ | ++++ | ++ | ++* | A611V and stop codon at base 45207 |
| nu345 | +++ | + | ++++ | ++++ | + | ++++ | G1077E |
| n2467 | ++ | − | +++ | ++++ | + | ++* | ? |
| nu319ts | + | − | +++ | − | − | +* | ? |
| dig-1 allele . | PVQ soma . | PVQ axon . | Amphid neurons . | AVK soma . | AVK axon . | Gonad . | Molecular lesion . |
|---|---|---|---|---|---|---|---|
| Wild type | − | − | − | − | − | − | − |
| ky188 | ++ | +++ | ++ | ++ | ++ | + | ? |
| ky199 | +++ | + | +++ | ++++ | + | ++++ | 11 bp deletion at codon 2083, out of frame |
| ky201 | +++ | + | +++ | ++++ | +++ | +++ | ? |
| n1321 | ++ | − | ++++ | +++ | + | ++++* | Stop codon at base 8367 |
| n1480 | +++ | − | ++ | ++++ | + | +++* | insertion/deletion in repetitive region* |
| nu336 | +++† | − | +++ | +++ | + | +* | Missense in repetitive region* |
| nu52 | ++ | − | ++ | ++++ | ++ | ++* | A611V and stop codon at base 45207 |
| nu345 | +++ | + | ++++ | ++++ | + | ++++ | G1077E |
| n2467 | ++ | − | +++ | ++++ | + | ++* | ? |
| nu319ts | + | − | +++ | − | − | +* | ? |
ky188 is the most severe for phenotypes relating to axon positioning, while nu345 and n1321 are most severe for phenotypes relating to cell body position.
− Wild-type phenotype.
++ Mild phenotype.
+++ Moderate phenotype.
++++ Severe phenotype.
E. Ryder, personal communication.
High expressivity; cell bodies severely mispositioned.