Skip to Main Content
Table 2.

Phenotypic comparison of dig-1 alleles

dig-1 allelePVQ somaPVQ axonAmphid neuronsAVK somaAVK axonGonadMolecular lesion
Wild type − − − − − − − 
ky188 ++ +++ ++ ++ ++ 
ky199 +++ +++ ++++ ++++ 11 bp deletion at codon 2083, out of frame 
ky201 +++ +++ ++++ +++ +++ 
n1321 ++ − ++++ +++ ++++* Stop codon at base 8367 
n1480 +++ − ++ ++++ +++* insertion/deletion in repetitive region* 
nu336 +++ − +++ +++ +* Missense in repetitive region* 
nu52 ++ − ++ ++++ ++ ++* A611V and stop codon at base 45207 
nu345 +++ ++++ ++++ ++++ G1077E 
n2467 ++ − +++ ++++ ++* 
nu319ts − +++ − − +* 
dig-1 allelePVQ somaPVQ axonAmphid neuronsAVK somaAVK axonGonadMolecular lesion
Wild type − − − − − − − 
ky188 ++ +++ ++ ++ ++ 
ky199 +++ +++ ++++ ++++ 11 bp deletion at codon 2083, out of frame 
ky201 +++ +++ ++++ +++ +++ 
n1321 ++ − ++++ +++ ++++* Stop codon at base 8367 
n1480 +++ − ++ ++++ +++* insertion/deletion in repetitive region* 
nu336 +++ − +++ +++ +* Missense in repetitive region* 
nu52 ++ − ++ ++++ ++ ++* A611V and stop codon at base 45207 
nu345 +++ ++++ ++++ ++++ G1077E 
n2467 ++ − +++ ++++ ++* 
nu319ts − +++ − − +* 

ky188 is the most severe for phenotypes relating to axon positioning, while nu345 and n1321 are most severe for phenotypes relating to cell body position.

− Wild-type phenotype.

++ Mild phenotype.

+++ Moderate phenotype.

++++ Severe phenotype.

*

E. Ryder, personal communication.

High expressivity; cell bodies severely mispositioned.

Close Modal

or Create an Account

Close Modal
Close Modal