Cell proliferation in E12.5 control and Fgf9-/- GI tracts
| . | . | . | Epithelium . | . | Mesenchyme . | . | ||
|---|---|---|---|---|---|---|---|---|
| Tissue . | Genotype . | n* . | % BrdU±s.d. . | Pvalue† . | % BrdU±s.d. . | Pvalue† . | ||
| Cecum | +/+, +/- | 5 | 49±5 | 43±2‡ | ||||
| -/- | 3 | 30±5§ | P<0.01 | 23±1§ | P<0.0001 | |||
| Small intestine | +/+, +/- | 6 | 46±5 | 34±5‡ | ||||
| -/- | 6 | 50±3§ | ns | 36±3§ | ns | |||
| Colon | +/+, +/- | 6 | 50±2 | 42±5 | ||||
| -/- | 6 | 51±3§ | ns | 41±4§ | ns | |||
| . | . | . | Epithelium . | . | Mesenchyme . | . | ||
|---|---|---|---|---|---|---|---|---|
| Tissue . | Genotype . | n* . | % BrdU±s.d. . | Pvalue† . | % BrdU±s.d. . | Pvalue† . | ||
| Cecum | +/+, +/- | 5 | 49±5 | 43±2‡ | ||||
| -/- | 3 | 30±5§ | P<0.01 | 23±1§ | P<0.0001 | |||
| Small intestine | +/+, +/- | 6 | 46±5 | 34±5‡ | ||||
| -/- | 6 | 50±3§ | ns | 36±3§ | ns | |||
| Colon | +/+, +/- | 6 | 50±2 | 42±5 | ||||
| -/- | 6 | 51±3§ | ns | 41±4§ | ns | |||
s.d., standard deviation.
ns, non-significant difference.
n, number of mice counted
P value, two-tail P value from a two-sample t-test assuming equal variances for % BrdU labeled nuclei in Fgf9-/- tissue compared with wild-type or Fgf9+/- tissue
P<0.001, comparison of the BrdU-labeling index in cecal and small intestinal mesenchyme from wild-type mice
P<0.0001, comparison of the BrdU-labeling index in cecal and small intestine and colon epithelium and mesenchyme from Fgf9-/- mice