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Table 4.

Effects of reagents on the area of organ culture

Whole metanephroi
Mesenchymal rudiments
ReagentnArea at day 7 (mean ± s.d.) (mm2)PnArea at day 7 (mean ± s.d.) (mm2)P
Control (without reagents) 1.717±0.381  1.912±0.200  
HIV-TAT peptide 1.500±0.215 0.12 1.838±0.364 0.33 
JNK inhibitor 1 1.020±0.325 <0.005 0.651±0.131 <0.001 
JNK inhibitor 2 1.105±0.260 <0.005 1.078±0.377 <0.001 
Y27,632 2.871±0.879 <0.01 3.401±0.433 <0.001 
LiCl 0.716±0.070 <0.001 1.270±0.238 <0.001 
Whole metanephroi
Mesenchymal rudiments
ReagentnArea at day 7 (mean ± s.d.) (mm2)PnArea at day 7 (mean ± s.d.) (mm2)P
Control (without reagents) 1.717±0.381  1.912±0.200  
HIV-TAT peptide 1.500±0.215 0.12 1.838±0.364 0.33 
JNK inhibitor 1 1.020±0.325 <0.005 0.651±0.131 <0.001 
JNK inhibitor 2 1.105±0.260 <0.005 1.078±0.377 <0.001 
Y27,632 2.871±0.879 <0.01 3.401±0.433 <0.001 
LiCl 0.716±0.070 <0.001 1.270±0.238 <0.001 

n, number of explants measured. P values were analyzed against control by using a t-test. Data from five independent experiments each for whole metanephroi and mesenchyme rudiments are shown.

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