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Table 4.

FGF/ERK signalling negatively regulates the activity of Casanova at the animal pole

RNA injected at the 16-cell stageCasanova-WTCasanova-S47ACasanova-WT + SU5402Casanova-WT + Mkp3Casanova-WT + Erk2*Casanova-S47A + Erk2*
% Embryos showing ectopic sox17 expression 30 46 49 64 54 
Total number of embryos 381 214 182 205 167 118 
RNA injected at the 16-cell stageCasanova-WTCasanova-S47ACasanova-WT + SU5402Casanova-WT + Mkp3Casanova-WT + Erk2*Casanova-S47A + Erk2*
% Embryos showing ectopic sox17 expression 30 46 49 64 54 
Total number of embryos 381 214 182 205 167 118 
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