Inhibition of the FGF pathway increases the number of sox17-expressing cells and partially rescues heart morphogenesis in bonnie and clyde mutants
| . | bon-/- . | bon-/- + SU5402 . | bon-/- + Fgf8 and Fgf24 MOs . |
|---|---|---|---|
| Average number of cells expressing sox17 per embryo at about 80%epiboly | 11 (n=12) | 37 (n=13) | Not determined |
| Average number of sox17-expressing cells at about 90% epiboly | 22 (n=38) | Not determined | 28 (n=25) |
| Percentage of embryos with cardia bifida at 30 hpf | 19 (n=62) | 9 (n=403) | 2 (n=86) |
| . | bon-/- . | bon-/- + SU5402 . | bon-/- + Fgf8 and Fgf24 MOs . |
|---|---|---|---|
| Average number of cells expressing sox17 per embryo at about 80%epiboly | 11 (n=12) | 37 (n=13) | Not determined |
| Average number of sox17-expressing cells at about 90% epiboly | 22 (n=38) | Not determined | 28 (n=25) |
| Percentage of embryos with cardia bifida at 30 hpf | 19 (n=62) | 9 (n=403) | 2 (n=86) |