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Table 2.

Inhibition of the FGF pathway increases the number of sox17-expressing cells and partially rescues heart morphogenesis in bonnie and clyde mutants

bon-/-bon-/- + SU5402bon-/- + Fgf8 and Fgf24 MOs
Average number of cells expressing sox17 per embryo at about 80%epiboly 11 (n=12) 37 (n=13) Not determined 
Average number of sox17-expressing cells at about 90% epiboly 22 (n=38) Not determined 28 (n=25) 
Percentage of embryos with cardia bifida at 30 hpf 19 (n=62) 9 (n=403) 2 (n=86) 
bon-/-bon-/- + SU5402bon-/- + Fgf8 and Fgf24 MOs
Average number of cells expressing sox17 per embryo at about 80%epiboly 11 (n=12) 37 (n=13) Not determined 
Average number of sox17-expressing cells at about 90% epiboly 22 (n=38) Not determined 28 (n=25) 
Percentage of embryos with cardia bifida at 30 hpf 19 (n=62) 9 (n=403) 2 (n=86) 
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