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Table 3.

Double inhibition of the FGF and BMP pathways causes formation of an excess of endoderm precursors at 75% epiboly

RNA injected at the one-cell stageWild typeNogginDN RasDN Ras + NogginFgf8, Fgf17b and Fgf24 MOsFgf8, Fgf17b and Fgf24 MOs + Noggin
Average number of sox17-positive cells per embryo 437±47 498±89 354±64 652±87 802±63 1000±172 
Total number of embryos 14 10 15 15 
RNA injected at the one-cell stageWild typeNogginDN RasDN Ras + NogginFgf8, Fgf17b and Fgf24 MOsFgf8, Fgf17b and Fgf24 MOs + Noggin
Average number of sox17-positive cells per embryo 437±47 498±89 354±64 652±87 802±63 1000±172 
Total number of embryos 14 10 15 15 
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