Protein type . | C. elegans§ . | Drosophila¶ . | Xenopus** . | S. cerevisiae†† . | Homo sapiens‡‡(HeLa cells) . |
---|---|---|---|---|---|
DEAD-box helicase | CGH-1 | Me31B | Xp54 | Dhh1 | RCK |
Sm-like domain | CAR-1* | Tral* | ? | ? | ? |
CPEB family | CPB-3‡ | Orb† | CPEB* | — | CPEB1† |
Y-box | CEY-2, 3, 4* | Yps* | FRGY2* | ? | ? |
Cap-binding | ? | eIF4E* | eIF4E† | ? | ? |
eIF4E-binding | — | Cup* | Maskin† | — | — |
— | Exu* | — | — | — | |
5′-3′ mRNA decay machinery | ? | ? | ? | Lsm*,Dcp1*,Dcp2*,Xrn1* | hDcp1a†,hDcp1b†,hDcp2†,hLsm†,hCcr4† |
Protein type . | C. elegans§ . | Drosophila¶ . | Xenopus** . | S. cerevisiae†† . | Homo sapiens‡‡(HeLa cells) . |
---|---|---|---|---|---|
DEAD-box helicase | CGH-1 | Me31B | Xp54 | Dhh1 | RCK |
Sm-like domain | CAR-1* | Tral* | ? | ? | ? |
CPEB family | CPB-3‡ | Orb† | CPEB* | — | CPEB1† |
Y-box | CEY-2, 3, 4* | Yps* | FRGY2* | ? | ? |
Cap-binding | ? | eIF4E* | eIF4E† | ? | ? |
eIF4E-binding | — | Cup* | Maskin† | — | — |
— | Exu* | — | — | — | |
5′-3′ mRNA decay machinery | ? | ? | ? | Lsm*,Dcp1*,Dcp2*,Xrn1* | hDcp1a†,hDcp1b†,hDcp2†,hLsm†,hCcr4† |
Evidence indicates that these proteins interact either physically or functionally with CGH-1 or its ortholog in the species shown.
Proteins that have been isolated in a RNP complex along with a CGH-1 ortholog.
Colocalization with proteins that interact with CGH-1 orthologs.
Predicted functional interaction with CGH-1 (see text).
This work.
Mansfield et al., 2002; Nakamura et al., 2001; Nakamura et al., 2004; Wilhelm et al., 2003; Wilhelm et al., 2000.
Ladomery et al., 1997; Minshall and Standart, 2004; Stebbins-Boaz et al.,1999.
Sheth and Parker, 2003; Tharun et al., 2000.
See Cougot et al., 2004; Eystathioy et al., 2003; Ingelfinger et al., 2002; Wilczynska et al., 2005. Human cytoplasmic RNA degradation particles that contain RCK have been designated as dcp1 or GW bodies, but for simplicity we refer to them here as P bodies.
, Unambiguous ortholog in genome, but no functional information available.
, No clear ortholog has been described.