Genetic interaction of Pbx1 and Hox11 in vivo during spleen organogenesis
| Spleen phenotype . | Pbx1−/−; Hox11 wild type . | Pbx1 wild type; Hox11−/− . | Pbx1 wild type; Hox11 wild type . | Pbx1+/−; Hox11 wild type . | Pbx1 wild type; Hox11+/− . | Pbx1+/−; Hox11+/− . |
|---|---|---|---|---|---|---|
| Asplenia | 100% | 100% | 0% | 0% | 0% | 0% |
| Spleen malformations | 4% | 9% | 6% | 80% | ||
| Indentations | Indentations | Indentations | Sickle form, indentations, tubercles, nodules, protuberances, fusion of two spleens |
| Spleen phenotype . | Pbx1−/−; Hox11 wild type . | Pbx1 wild type; Hox11−/− . | Pbx1 wild type; Hox11 wild type . | Pbx1+/−; Hox11 wild type . | Pbx1 wild type; Hox11+/− . | Pbx1+/−; Hox11+/− . |
|---|---|---|---|---|---|---|
| Asplenia | 100% | 100% | 0% | 0% | 0% | 0% |
| Spleen malformations | 4% | 9% | 6% | 80% | ||
| Indentations | Indentations | Indentations | Sickle form, indentations, tubercles, nodules, protuberances, fusion of two spleens |
Percentage of mice exhibiting the indicated spleen phenotype. Data are from 30-60 mice (6 to 8 weeks old) of each genotype.