The Company of Biologists

Table 1.

Phenotypes in normal and abnormal uterine and cervicovaginal epithelia

		Müllerian vagina/cervix					Uterus
		p63⁺				p63⁺				UtE/VgS-TR
	Müllerian duct (E16)	Normal^{^†}	Adenosis^*	p63^-/-^*	Normal	SQM^{^†}	p63^-/-	p63⁺^*
Epithelial type	Columnar	Squamous	Columnar	Columnar	Columnar	Squamous	Columnar	Columnar
Inclusion/gland	-	-	+	+	+	-	+	+
ERα	-	+	+	+	+	+	+	+
p130	-	+	+	+	+	+	+	+
p63	-	+	-	-	-	+	-	-
K14	-	+	-	-	-	+	-	-
K19	-	+	-	-	-	+	-	-
P-cadherin	-	+	-	-	-	+	-	-
K10	-	+	-	-	-	+	-	-
Involucrin	-	+	-	-	-	+	-	-
K8	+	-^{^‡}	+	+	+	-	+	+
PR (-E2)	-	-	+	+	+	-	+	+
PR (+E2)	-	+	+	+	-	+	-	+

		Müllerian vagina/cervix					Uterus
		p63⁺				p63⁺				UtE/VgS-TR
	Müllerian duct (E16)	Normal^{^†}	Adenosis^*	p63^-/-^*	Normal	SQM^{^†}	p63^-/-	p63⁺^*
Epithelial type	Columnar	Squamous	Columnar	Columnar	Columnar	Squamous	Columnar	Columnar
Inclusion/gland	-	-	+	+	+	-	+	+
ERα	-	+	+	+	+	+	+	+
p130	-	+	+	+	+	+	+	+
p63	-	+	-	-	-	+	-	-
K14	-	+	-	-	-	+	-	-
K19	-	+	-	-	-	+	-	-
P-cadherin	-	+	-	-	-	+	-	-
K10	-	+	-	-	-	+	-	-
Involucrin	-	+	-	-	-	+	-	-
K8	+	-^{^‡}	+	+	+	-	+	+
PR (-E2)	-	-	+	+	+	-	+	+
PR (+E2)	-	+	+	+	-	+	-	+

Epithelial phenotypes of p63⁺ cervicovaginal adenosis, p63^-/- cervix/vagina and adult-UtE+VgS tissue recombinants were identical.

Epithelial phenotypes of p63⁺ cervix/vagina and uterine SQM were identical.

Vagina only.