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Table 1.

The effect of mis-expression of wild-type and mutant Dup proteins

TransgeneRe-replication*Cell deathAmplification
None — — 
FL-Dup 
N-Dup — — 
C-Dup — — +++ 
Dup 10(A) ++ ++ — 
TransgeneRe-replication*Cell deathAmplification
None — — 
FL-Dup 
N-Dup — — 
C-Dup — — +++ 
Dup 10(A) ++ ++ — 
*

—, Wild-type nuclei; +, enlarged nuclei, >4C DNA content; ++, many enlarged nuclei, increased fraction >4C DNA content

—, Wild-type nuclei; +, pycnotic nuclei, Acridine Orange and activated caspase staining; ++, many pycnotic nuclei, Acridine Orange and activated caspase staining

+, Wild-type appearance of BrdU amplification foci; +++, increased;—, no BrdU

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