Phenotypes associated with kidney malformations by human SPRY2expression
| . | WT/TG kidneys . | . | . | . | TG/TG kidneys . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stage . | Number analysed . | Reduced (%) . | Cystic (%) . | Ectopic (%) . | Number analysed . | Reduced (%) . | Cystic (%) . | Ectopic (%) . | ||||||
| E15.5 | 42 | 40 (95.24) | 0 | 2 (4.76) | 23 | 17 (73.91) | 5 (21.74) | 1 (4.35) | ||||||
| E17.5 | 9 | 33 (84.62) | 2 (5.13) | 4 (10.25) | 12 | 10 (83.33) | 2 (16.67) | 0 | ||||||
| Newborn | 150 | 122 (81.33) | 10 (6.67) | 18 (12.00) | 26 | 20 (76.92) | 4 (15.39) | 2 (7.69) | ||||||
| Total | 231 | 195 (84.42) | 12 (5.19) | 24 (10.39) | 61 | 47 (77.05) | 11 (18.03) | 3 (4.92) | ||||||
| . | WT/TG kidneys . | . | . | . | TG/TG kidneys . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stage . | Number analysed . | Reduced (%) . | Cystic (%) . | Ectopic (%) . | Number analysed . | Reduced (%) . | Cystic (%) . | Ectopic (%) . | ||||||
| E15.5 | 42 | 40 (95.24) | 0 | 2 (4.76) | 23 | 17 (73.91) | 5 (21.74) | 1 (4.35) | ||||||
| E17.5 | 9 | 33 (84.62) | 2 (5.13) | 4 (10.25) | 12 | 10 (83.33) | 2 (16.67) | 0 | ||||||
| Newborn | 150 | 122 (81.33) | 10 (6.67) | 18 (12.00) | 26 | 20 (76.92) | 4 (15.39) | 2 (7.69) | ||||||
| Total | 231 | 195 (84.42) | 12 (5.19) | 24 (10.39) | 61 | 47 (77.05) | 11 (18.03) | 3 (4.92) | ||||||
The left panel indicates those embryos and newborn mice that were scored carriers of the hSprouty2 transgene in their genome while those on the right column represent samples that are obtained from crosses of two transgenic mouse. Inheritance of the transgene from the female and male increases the % of cytogenesis and induce also unilateral agenesis of the kidney.