The Company of Biologists

Table 1.

Molecular basis of amos mutations

Allele	DNA	Protein	Predicted effect	Phenotype
amos¹	C₅₅₀>T₅₅₀	Q₁₈₄>Stop	Truncates the bHLH domain	Strong hypomorph/null
amos²	G₄₅₈>A₄₅₈	S₁₅₃>N₁₅₃	Substitution in bHLH domain	Moderate hypomorph
amos³	230 bp deletion+frameshift		Severely truncated protein	Null?

Allele	DNA	Protein	Predicted effect	Phenotype
amos¹	C₅₅₀>T₅₅₀	Q₁₈₄>Stop	Truncates the bHLH domain	Strong hypomorph/null
amos²	G₄₅₈>A₄₅₈	S₁₅₃>N₁₅₃	Substitution in bHLH domain	Moderate hypomorph
amos³	230 bp deletion+frameshift		Severely truncated protein	Null?