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Table 2.

Summary of motor axon guidance defects in unc-71 mutants and transgenes

Axon defects
Longitudinal defasciculation(penetrance/extent)*Commissural defects
GenotypeOutgrowth failureLR asymmetryGuidance defects§Vd13 defects
juIs76[Punc-25GFP] <1 <1 
unc-71(ju156); juIs76 (L1 larvae) NA 33 32 21 NA 
unc-71(ju156); juIs76 100/36.4 39 39 21 100 
unc-71(ju255); juIs76 25/10 30 70 
juIs14[Pacr-2GFP] NA 
unc-71(ju156); juIs14 30/ND 7.1 2.4 NA 
juIs76; juEx[Punc-115UNC-71(ECD)] 16 11 
juIs76; juEx[Punc-115UNC-71(+)] 
Axon defects
Longitudinal defasciculation(penetrance/extent)*Commissural defects
GenotypeOutgrowth failureLR asymmetryGuidance defects§Vd13 defects
juIs76[Punc-25GFP] <1 <1 
unc-71(ju156); juIs76 (L1 larvae) NA 33 32 21 NA 
unc-71(ju156); juIs76 100/36.4 39 39 21 100 
unc-71(ju255); juIs76 25/10 30 70 
juIs14[Pacr-2GFP] NA 
unc-71(ju156); juIs14 30/ND 7.1 2.4 NA 
juIs76; juEx[Punc-115UNC-71(ECD)] 16 11 
juIs76; juEx[Punc-115UNC-71(+)] 

Unless noted, data were collected from 50 young adult animals expressing juIs76[Punc-25GFP] or juIs14[Pacr-2GFP].

All data were collected from four or more independent lines.

The total% of both stalling and U-shaped morphology in VD13.

*

% animals exhibiting defasciculation defects/% defasciculated VD neurons

% commissures that failed to exit the ventral cord in a single animal(divided by 17)

Commissures on the left side in a single animal (divided by total number of commissures)

§

% commissures that stopped prematurely in a single animal (divided by total number of commissures)

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