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Table 1.

Molecular lesions of unc-71 mutants

AlleleNucleotide changeAmino acid changeDomains
ju161 GGA→AGA G149R Prodomain 
ju156 170 bp deletion G149 Prodomain 
ay64 GAT→AAT D461N Disintegrin 
ay46, ay51 CTC→CCL471P Disintegrin 
ay17, ad487 TGT→TAC477Y Disintegrin 
ay49 CGA→TGA R490opal Disintegrin 
ju160 GAC→AAC D504N Disintegrin 
ju159 TGT→TAC509Y Disintegrin 
ay45, ay50 CAA→TAA Q533ochre Cys rich 
ay52 TGG→TGA W550opal Cys rich 
ju194 GGA→TGA G551opal Cys rich 
e541 GCG→ACG A557T Cys rich 
ju157 GGA→GAG594E Cys rich 
ay7 CAA→TAA Q623ochre Cys rich 
ay47 TCG→TTS628L Cys rich 
ay44 TGT→AGT C687S EGF like 
ay48 CCA→CTP902L Cytoplasmic 
 CAA→TAA Q948opal Cytoplasmic 
ju255 AGA→AAR990K Cytoplasmic 
AlleleNucleotide changeAmino acid changeDomains
ju161 GGA→AGA G149R Prodomain 
ju156 170 bp deletion G149 Prodomain 
ay64 GAT→AAT D461N Disintegrin 
ay46, ay51 CTC→CCL471P Disintegrin 
ay17, ad487 TGT→TAC477Y Disintegrin 
ay49 CGA→TGA R490opal Disintegrin 
ju160 GAC→AAC D504N Disintegrin 
ju159 TGT→TAC509Y Disintegrin 
ay45, ay50 CAA→TAA Q533ochre Cys rich 
ay52 TGG→TGA W550opal Cys rich 
ju194 GGA→TGA G551opal Cys rich 
e541 GCG→ACG A557T Cys rich 
ju157 GGA→GAG594E Cys rich 
ay7 CAA→TAA Q623ochre Cys rich 
ay47 TCG→TTS628L Cys rich 
ay44 TGT→AGT C687S EGF like 
ay48 CCA→CTP902L Cytoplasmic 
 CAA→TAA Q948opal Cytoplasmic 
ju255 AGA→AAR990K Cytoplasmic 

ju mutations were isolated in the screen for axon guidance mutants using juIs76 [Punc-25GFP] marker(Huang et al., 2002). ay mutants were isolated in sem-5 background(Chen et al., 1997). The underlined letters correspond to the nucleotide alterations. The standard single letter code for each amino acid is used.

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