Wnt11 and Ret mutations synergistically interact to yield kidney hypoplasia
| Genotype . | Number of glomeruli (±s.d.) . | n . |
|---|---|---|
| Ret+/+; Wnt11+/+ | 1358±258 | 4 |
| Ret+/-; Wnt11+/+ | 1447±278 | 4 |
| Ret+/+; Wnt11-/- | 1055±161 | 4 |
| Ret+/-; Wnt11+/- | 702±40 | 5 |
| Ret+/-; Wnt11-/- | 469±131 | 10 |
| Genotype . | Number of glomeruli (±s.d.) . | n . |
|---|---|---|
| Ret+/+; Wnt11+/+ | 1358±258 | 4 |
| Ret+/-; Wnt11+/+ | 1447±278 | 4 |
| Ret+/+; Wnt11-/- | 1055±161 | 4 |
| Ret+/-; Wnt11+/- | 702±40 | 5 |
| Ret+/-; Wnt11-/- | 469±131 | 10 |
Average total numbers of glomeruli in E18.5 kidneys from Ret;Wnt11double mutant combinations are shown. Ret+/-;Wnt11+/- kidneys contain fewer glomeruli than wild-type controls. Ret+/-;Wnt11-/- kidneys are much smaller than either Ret+/- or Wnt11-/-kidneys by themselves. Ret+/- kidneys are not statistically significantly different in size from genotypically wild-type controls. Glomeruli were counted from 6 μm coronal Hematoxylin/Eosin stained kidney sections.