Quantification of ureteric tips loss in Wnt11-/-kidneys
| Number of ureteric tips . | Wild type(%) (n=57) . | Wnt11-/-(%) (n=11) . |
|---|---|---|
| 8 | 5 | 0 |
| 7 | 42 | 0 |
| 6 | 49 | 0 |
| 5 | 4 | 64 |
| 4 | 0 | 36 |
| Number of ureteric tips . | Wild type(%) (n=57) . | Wnt11-/-(%) (n=11) . |
|---|---|---|
| 8 | 5 | 0 |
| 7 | 42 | 0 |
| 6 | 49 | 0 |
| 5 | 4 | 64 |
| 4 | 0 | 36 |
Ureteric tips from E12.5 wild-type and Wnt11-/- kidneys hybridized with Ret antisense probe were counted. The percentage of kidneys (n=57 for wild type, 11 for mutant) with eight, seven, six,five or four tips is shown. Wnt11-/- kidneys show a statistically significant (P<0.001) difference from wild-type frequencies for the distribution of ureteric tips.