Wnt11-/- kidneys have reduced numbers of nephrons
| Genotype . | Number of glomeruli (±s.d.) . | n . |
|---|---|---|
| Wnt11+/+ | 1934±148 | 6 |
| Wnt11+/- | 1804±52 | 4 |
| Wnt11-/- | 1237±135 | 6 |
| Genotype . | Number of glomeruli (±s.d.) . | n . |
|---|---|---|
| Wnt11+/+ | 1934±148 | 6 |
| Wnt11+/- | 1804±52 | 4 |
| Wnt11-/- | 1237±135 | 6 |
In order to quantify kidney size, the numbers of nephron glomeruli in Wnt11+/+, Wnt11+/- and Wnt11-/- P1 kidneys were counted from 6 μm Hematoxylin and Eosin stained sections. Wnt11-/- kidneys contain∼64% (P=0.0001) the number of glomeruli compared with Wnt11+/+. Wnt11+/- kidneys are not statistically significantly different in size from genotypically wild-type kidneys.