... to generate multiple splice variants (as many as 16 in the case of NBCn1 ), each of which could have unique temporal and spatial patterns of distribution, unitary transporter activity (i.e. flux mediated by one molecule), array of protein-binding partners, and complement of regulatory stimuli. In the first...

... splice variants in teleosts and terrestrial vertebrates( Briggs et al., 1994 ; Briggs and Schachat, 1993 ; Morgan et al., 1993 ; Wang and Jin, 1997 ), may suggest that the foetal/embryonic-specific exon arose before fish and terrestrial vertebrates diverged and that similar constraints exist in early...