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Keywords: spironolactone
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Journal Articles
J Exp Biol (2011) 214 (14): 2308–2318.
Published: 15 July 2011
...), and cortisol treatment significantly increased transepithelial resistance (TER) and decreased paracellular [ 3 H]PEG-4000 flux. Epithelial permeability was unaffected by deoxycorticosterone or aldosterone. The GR antagonist RU486 as well as MR antagonists spironolactone and RU26752 significantly reduced...
Journal Articles
J Exp Biol (2009) 212 (12): 1849–1858.
Published: 15 June 2009
... of metyrapone, blocking cortisol receptors through exposure to either RU-486 (GR antagonist) and spironolactone (MR antagonist), or through exogenous infusion of the tetrapod mineralocorticoid aldosterone (tetrapod MR agonist). The data demonstrate that lowering the activity of cortisol, either by inhibiting...
Journal Articles
J Exp Biol (2001) 204 (22): 3953–3961.
Published: 15 November 2001
... RU486 and spironolactone. RU486 is a potent antagonist of the glucocorticoid actions of cortisol, whereas spironolactone exhibits high-affinity binding to mineralocorticoid receptors, with a resulting blockade of mineralocorticoid properties in mammals. Untreated rainbow trout, as well as rainbow trout...