... and nerve bundles, and immunohistochemistry using a neural NOS antibody showed a similar distribution of neural NOS immunoreactivity in the perivascular nerves. In vitro organ bath physiology showed that a NO/soluble guanylyl cyclase (GC) system is present in the dorsal aorta and the intestinal vein, since...

..., but previous pharmacological studies on the cardiac stomach using the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazol[4,3-a]quinoxalin-1-one (ODQ) indicate that the cyclic nucleotide second messenger cGMP may mediate effects of NO. Consistent with this hypothesis, here we report that ODQ also causes...

..., atropine (10 -6 mol l -1 ) (a muscarinic receptor inhibitor), L-NNA (10 -4 mol l -1 ) (a NOS inhibitor) and ODQ (10 -5 mol l -1 ) (an inhibitor of soluble guanylyl cyclase) abolished the vasodilatory effect of applied acetylcholine. In conclusion, we propose that an endothelial NO system is absent in toad...

...Georg F. Rast SUMMARY The stimulatory effects of nitric oxide (NO) on central motor pattern generation in isolated locust suboesophageal ganglia (SOGs) were studied using extracellular recordings from motor nerves. Different NO donor molecules and a specific inhibitor of soluble guanylyl cyclases...

...) is a soluble guanylyl cyclase (SGC) inhibitor that acts by preventing interaction between NO and the haem moeity of SGC ( Schrammel et al., 1996 ). (B) SNAP-induced relaxation of the cardiac stomach. (C) L-Arginine (L-Arg)-induced relaxation of the cardiac stomach. (D) Graph showing the mean (+ S.E.M.; N =5...

...Oliver Schmachtenberg; Gerd Bicker ABSTRACT Nitric oxide (NO) is a membrane-permeant messenger molecule which activates the cyclic GMP (cGMP)-synthesizing enzyme soluble guanylyl cyclase. Using cytochemical techniques, we recently reported NO-induced cGMP immunoreactivity in the photoreceptor cells...