... the plasma membrane or acidifying intracellular compartments. The former process plays a critical role in proton secretion by the kidney and regulates systemic acid–base status whereas the latter process is central to intracellular vesicle trafficking, membrane recycling and the degradative pathway in cells...

... in intracellular pH (pHi) that was dependent on Ca 2+ influx from the extracellular medium as well as Ca 2+ release from intracellular pools. Surprisingly, this increase in pHi and intracellular Ca 2+ concentration,[Ca 2+ ] i , was not accompanied by any change in proton secretion. By contrast, removal...

... investigated the signalling mechanisms underlying NHE activation under these conditions. Exposing trout hepatocytes to cariporide, a specific inhibitor of NHE-1, decreased baseline pHi,completely blocked the hypertonicity-induced increase of pHi and reduced the hypertonicity-induced proton secretion by 80...

... species, saccular endolymph was characterized by high levels of K + and total CO 2 and in trout by an alkaline pH. The kinetic characteristics of proton secretion across the saccular epithelium of trout were investigated using a titration technique in which isolated saccules were mounted as closed sacs...