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Keywords: proteomics
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Journal Articles
J Exp Biol (2022) 225 (15): jeb244218.
Published: 11 August 2022
... predicts that ectothermic organisms from thermally stable environments have muted plasticity, and that these species may be particularly vulnerable to temperature increases. Whether such species retained or lost acclimation capacity remains largely unknown. We studied proteome changes in the planarian...
Includes: Supplementary data
Journal Articles
J Exp Biol (2022) 225 (4): jeb243572.
Published: 21 February 2022
... and resistance to oxidative stress during fasting. However, the cellular mechanisms that regulate these adaptations are still not fully understood. To examine how metabolic coordination is achieved during prolonged fasting, we profiled changes in blubber, skeletal muscle and plasma proteomes of adult female NES...
Includes: Supplementary data
Journal Articles
J Exp Biol (2021) 224 (22): jeb242820.
Published: 18 November 2021
... to their thermal maxima, stress response mechanisms found in these organisms are poorly understood. We used a novel physiological–proteomic approach for sponges to describe the stress response mechanisms of the lagoon-inhabiting sponge Amphimedon navalis , when exposed to elevated seawater temperatures of +2°C...
Includes: Supplementary data
Journal Articles
J Exp Biol (2021) 224 (3): jeb230342.
Published: 9 February 2021
... the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog ( Oophaga sylvatica ) to determine how quickly alkaloids are accumulated and how toxins modify frog physiology using quantitative proteomics. Diablito frogs...
Includes: Supplementary data
Journal Articles
J Exp Biol (2019) 222 (12): jeb204149.
Published: 20 June 2019
... as chemical defenses against predation. Although the dietary acquisition of chemical defenses in poison frogs is well documented, the physiological mechanisms of alkaloid sequestration has not been investigated. Here, we used RNA sequencing and proteomics to determine how alkaloids impact mRNA or protein...
Includes: Supplementary data
Journal Articles
J Exp Biol (2017) 220 (23): 4515–4534.
Published: 1 December 2017
... mechanisms influencing interspecific differences in stress tolerance are unknown, but are believed to be under regulation by sirtuins, nicotinamide adenine dinucleotide (NAD + )-dependent deacylases that play a critical role in the cellular stress response. A comparison of the proteomic responses of M...
Includes: Supplementary data
Journal Articles
J Exp Biol (2016) 219 (17): 2673–2686.
Published: 1 September 2016
..., the stressed organism can die. To better understand the earliest tissue-level responses to heat stress, we examined the proteomic response of gill from Geukensia demissa , an extremely eurythermal mussel from the temperate intertidal zone of eastern North America. We exposed 15°C-acclimated individuals...
Includes: Supplementary data
Journal Articles
J Exp Biol (2016) 219 (7): 969–976.
Published: 1 April 2016
... acclimation at the adult stage and focussed on adaptive responses. Here, we assessed the consequences of rearing Drosophila melanogaster at low (12°C), benign (25°C) and high (31°C) temperatures. We assessed cold and heat tolerance and obtained detailed proteomic profiles of flies from the three temperatures...
Includes: Supplementary data
Journal Articles
In collection:
Cardiology articles
J Exp Biol (2015) 218 (9): 1359–1372.
Published: 1 May 2015
...Nishad Jayasundara; Lars Tomanek; W. Wesley Dowd; George N. Somero ABSTRACT Cardiac function is thought to play a central role in determining thermal optima and tolerance limits in teleost fishes. Investigating proteomic responses to temperature in cardiac tissues may provide insights...
Includes: Supplementary data
Journal Articles
J Exp Biol (2015) 218 (3): 388–403.
Published: 1 February 2015
..., 1 h down-ramp to 10°C) and (3) 10–30°C (up-ramp to 30°C). After acclimation, animals were exposed to either 10°C or a 30°C heat shock to analyze the proteomic changes in claw muscle tissue. Following acclimation to 10–30°C (measured at 10°C), enolase and ATP synthase increased in abundance...
Includes: Supplementary data
Journal Articles
J Exp Biol (2014) 217 (9): 1601–1612.
Published: 1 May 2014
... metabolic responses. We examined proteomic responses to increasing emersion times and decreasing recovery (immersion) times in the mussel Geukensia demissa , which occurs in salt marshes along the east coast of North America. Individuals are found above mean tide level, and can be emersed for over 18 h...
Includes: Supplementary data
Journal Articles
J Exp Biol (2012) 215 (22): 3905–3916.
Published: 15 November 2012
... stress due to extreme precipitation events and freshwater runoff may be driving some of the reported recent range shifts in marine organisms. Using two-dimensional gel electrophoresis and tandem mass spectrometry, we characterized the proteomic responses of the cold-adapted blue mussel Mytilus trossulus...
Includes: Supplementary data
Journal Articles
J Exp Biol (2012) 215 (7): 1106–1116.
Published: 1 April 2012
... distributions of the response variables. We chose a P -value of 0.02 to limit the number of false positives instead of using a multiple-comparison correction. Because there is only limited overlap between the proteome maps of the two congeners, as well as uncertainty whether overlapping proteins were...
Includes: Supplementary data
Journal Articles
J Exp Biol (2011) 214 (11): 1836–1844.
Published: 1 June 2011
... proteomic changes associated with exposure to elevated P CO 2 in the mantle tissue of eastern oysters ( Crassostrea virginica ) after 2 weeks of exposure to control (∼39 Pa P CO 2 ) and hypercapnic (∼357 Pa P CO 2 ) conditions using two-dimensional gel electrophoresis and tandem mass spectrometry. Exposure...
Journal Articles
J Exp Biol (2010) 213 (20): 3559–3574.
Published: 15 October 2010
... of their proteomes to acute heat stress we sought to identify responses common to both species as well as differences that account for greater heat tolerance in the invasive. Mussels were acclimated to 13°C for four weeks and exposed to acute heat stress (24°C, 28°C and 32°C) for 1 h and returned to 13°C to recover...
Includes: Supplementary data
Journal Articles
J Exp Biol (2010) 213 (2): 210–224.
Published: 15 January 2010
...-offs and to evaluate the underlying mechanisms, we examined the responses of juvenile leopard sharks to salinity changes using a suite of measurements at multiple organizational levels: gill and rectal gland proteomes (using 2-D gel electrophoresis and tandem mass spectrometry), tissue biochemistry (Na...
Includes: Supplementary data
Journal Articles
J Exp Biol (2009) 212 (24): 4027–4032.
Published: 15 December 2009
... in learning change in synaptic and biochemical composition with increased foraging duration. First, we used synapse-specific immunohistochemistry and proteomics to screen for alterations in the calyx region of the mushroom body, a key structure for memory formation. Using proteomics, we next profiled...
Includes: Supplementary data
Journal Articles
J Exp Biol (2009) 212 (2): 184–193.
Published: 15 January 2009
... ) * These authors contributed equally to this work 3 11 2008 2009 muscle parvalbumin isometric force activation relaxation proteomics swimming Muscles power a huge diversity of activities requiring a wide range of mechanical properties; however, our understanding of the molecular...
Journal Articles
J Exp Biol (2007) 210 (9): 1593–1601.
Published: 1 May 2007
... to salinity adaptation. Functional genomics and proteomics approaches represent powerful tools for gaining insight into the molecular basis of salinity adaptation and euryhalinity in animals. In this review, we discuss our experience in applying such tools to so-called`non-model' species, including euryhaline...
Includes: Supplementary data
Journal Articles
J Exp Biol (2003) 206 (21): 3789–3802.
Published: 1 November 2003
...D. L. Doolan; J. C. Aguiar; W. R. Weiss; A. Sette; P. L. Felgner; D. P. Regis; P. Quinones-Casas; J. R. Yates, III; P. L. Blair; T. L. Richie; S. L. Hoffman; D. J. Carucci SUMMARY Recent advances in the fields of genomics, proteomics and molecular immunology offer tremendous opportunities...