... polymorphism in the gene phosphoglucose isomerase ( Pgi ) was significantly associated with both MR peak and lifespan, and may have coevolved with defence mechanisms against senescence. Generalisations such as ‘live fast, die young’ may be too simple to explain the complex processes affecting ageing...

... in pupae and resting adults but not in flying adults. There was also a consistent nonlinear effect of the time of the day, which was strongest in pupae and weakest in flying adults. Flight metabolic rate was strongly affected by an interaction between the phosphoglucose isomerase ( Pgi ) genotype...

..., phosphoglucose isomerase (PGI), which catalyzes a reaction believed to be close to equilibrium, occurs at V max values greatly in excess of glycolytic flux rates. In this study, we measure the V max of flight muscle PGI, the kinetic parameters of the purified enzyme, the apparent equilibrium constants...