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Keywords: mitochondria
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Journal Articles
J Exp Biol (2022) 225 (6): jeb243740.
Published: 16 March 2022
...., 2016 ; Janssens and Stoks, 2014 ). Cells primarily defend from excessive ROS via a suite of enzymatic and non-enzymatic antioxidants ( Halliwell, 2011 ). The primary ROS generated within the mitochondria is superoxide, which is rapidly converted to H 2 O 2 by superoxide dismutase (SOD). H 2 O 2...
Journal Articles
J Exp Biol (2022) 225 (Suppl_1): jeb243351.
Published: 8 March 2022
..., mitochondria and hypoxia-inducible factors, as well as convergent pathways involved in energy regulation, development, reproductive investment and energy storage. The details of these mechanisms are only known from a few model systems, and more comparative studies are needed. We make two main recommendations...
Journal Articles
J Exp Biol (2022) 225 (4): jeb196725.
Published: 21 February 2022
... response Ischaemia Mammals Metabolic rate suppression Mitochondria Thermoregulation Natural Sciences and Engineering Research Council of Canada http://dx.doi.org/10.13039/501100000038 Canada Research Chair Hypoxic environments are common in nature but despite...
Journal Articles
J Exp Biol (2022) 225 (1): jeb243304.
Published: 11 January 2022
... availability during hypoxia–reoxygenation (H/R). We investigated the effects of acute H/R stress (15 min at ∼0% O 2 and 10 min reoxygenation) on isolated mitochondria from the gill and the digestive gland of C. gigas respiring on different substrates (pyruvate, glutamate, succinate, palmitate...
Journal Articles
J Exp Biol (2021) 224 (21): jeb243082.
Published: 9 November 2021
... for its hypoxia tolerance associated with metabolic rate depression, yet the mechanisms that sustain mitochondrial function during oxygen fluctuations are not well understood. We used top-down metabolic control analysis (MCA) to determine aerobic capacity and control over oxygen flux in the mitochondria...
Includes: Supplementary data
Journal Articles
J Exp Biol (2021) 224 (18): jeb242634.
Published: 22 September 2021
... confirmed the involvement of K ATP in mitochondria with TMRE imaging, as hypoxia rapidly (<5 min) depolarized mitochondria in a mK ATP channel-sensitive manner. We conclude that mK ATP channels initiate a neuroprotective pathway in goldfish HCs to maintain [Ca 2+ ] i and avoid excitotoxicity in hypoxia...
Journal Articles
J Exp Biol (2021) 224 (17): jeb215764.
Published: 6 September 2021
... itself. Summary: This Commentary provides an update on recent advances on the role of hydrogen sulfide in mammalian hibernation, particularly on the mechanisms for the suppression of mitochondrial respiration during torpor. H 2 S Hypometabolism Mitochondria Sulfide:quinone oxidoreductase...
Journal Articles
J Exp Biol (2021) 224 (17): jeb242745.
Published: 3 September 2021
... of mitochondrial function and production of reactive oxygen species in the intertidal mud clam Mya arenaria . J. Exp. Biol. 205 , 1831 - 1841 . 10.1242/jeb.205.13.1831 Blier , P. U. , Lemieux , H. and Pichaud , N. ( 2014 ). Holding our breath in our modern world: will mitochondria keep...
Includes: Supplementary data
Journal Articles
J Exp Biol (2021) 224 (10): jeb242279.
Published: 1 June 2021
... respirometry on isolated iBAT mitochondria using substrates and inhibitors targeted to UCP-1. We found that rates of NST increased with cold hypoxia acclimation but only in highland deer mice. There was no effect of cold hypoxia acclimation on iBAT mass in any group, but highland deer mice showed increases...
Journal Articles
J Exp Biol (2021) 224 (9): jeb242382.
Published: 30 April 2021
...Jakob Michaelsen; Angela Fago; Amanda Bundgaard ABSTRACT Mitochondria provide cellular energy through oxidative phosphorylation, and thus temperature-induced constraints on mitochondrial function may be crucial to animal aerobic scope and thermal tolerance. Here, we report the effect of temperature...
Journal Articles
J Exp Biol (2020) 223 (21): jeb233684.
Published: 4 November 2020
... to conserve oxygen. The aim of the present study was to determine in vitro whether skeletal muscle mitochondria become more ‘thermogenic’ to sustain heat production or more ‘economical’ to conserve oxygen in sea-acclimatized immature penguins (hereafter ‘immatures’) compared with terrestrial juveniles. Rates...
Journal Articles
J Exp Biol (2020) 223 (20): jeb227801.
Published: 27 October 2020
... of mitochondrial processes, as mitochondria play a crucial role in animals as the primary site of ATP production. Conventional measures of mitochondrial performance suggest that these organelles can function at temperatures much higher than those that limit whole-organism function, suggesting...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (15): jeb222513.
Published: 4 August 2020
... of natural stressful developmental conditions reveals that glucocorticoid hormones induce telomere shortening by decreasing mitochondrial efficiency without altering oxidative stress, suggesting that telomeres are costly to maintain. Mitochondria Metabolism Proton leak Oxidative stress Telomere...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (12): jeb223776.
Published: 17 June 2020
..., and that 90% of CI is found in this highly stable SC. Interestingly, the presence of stable SCs did not prevent mitochondrial H 2 O 2 production and was not associated with elevated respiration rates of mitochondria isolated from the examined species. Together, these data show that SC stability varies among...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (2): jeb215921.
Published: 29 January 2020
... such as freshwater mussels. However, some species seem to thrive more than others in face of temperature-related stressors. Thermal tolerance may, for example, explain the success of invasive species. It is also known that mitochondria can play a key role in setting an ectothermic species' thermal tolerance...
Includes: Supplementary data
Journal Articles
J Exp Biol (2019) 222 (18): jeb203687.
Published: 18 September 2019
... of new feeding strategies, such as nutritional programming, to optimize the nutrition and health of farmed fish. Fish Mitophagy Mitochondria ER stress DNA and histone methylation Nutritional programming For more than 20 years, it has been widely accepted that nutritional stimuli...
Journal Articles
J Exp Biol (2019) 222 (17): jeb203521.
Published: 3 September 2019
... different rates of migration of genes located in the mitochondria versus the nucleus ( Darling et al., 2014 ). However, to our knowledge there have been no direct studies of how genotypic variation (either mitochondrial or nuclear) might translate into phenotypic variation in this system. There is some...
Includes: Supplementary data
Journal Articles
J Exp Biol (2019) 222 (11): jeb200410.
Published: 10 June 2019
...Amanda Bundgaard; Klaus Qvortrup; Lene Juel Rasmussen; Angela Fago ABSTRACT Mitochondria are important to cellular homeostasis, but can become a dangerous liability when cells recover from hypoxia. Anoxia-tolerant freshwater turtles show reduced mitochondrial respiratory capacity and production...
Journal Articles
J Exp Biol (2019) 222 (6): jeb191353.
Published: 18 March 2019
... function. Few species can survive prolonged periods of hypoxia and anoxia at tropical temperatures and those that do may rely on mitochondria plasticity in response to disruptions to oxygen availability. Two carpet sharks, the epaulette shark ( Hemiscyllium ocellatum ) and the grey carpet shark...
Journal Articles
J Exp Biol (2019) 222 (2): jeb189407.
Published: 28 January 2019
... generation among sculpin fishes (Cottidae, Actinopterygii) that are known to vary in whole-animal hypoxia tolerance. We hypothesized that mitochondria from hypoxia-tolerant sculpins would show more efficient O 2 use with a higher phosphorylation efficiency and lower ROS emission. We showed that brain...
Includes: Supplementary data