... hypoxic ventilatory response, robust metabolic rate suppression and decreased thermogenesis ( Mortola, 1999 ; Mortola et al., 1989 ). In most adult hypoxia-intolerant mammals, ventilatory and metabolic responses to hypoxia are regulated by excitatory glutamatergic signalling pathways ( Pamenter et al...

... ; Pamenter et al., 2015 ). A key finding was that naked mole-rats can suppress their metabolism by up to 85% in acute hypoxia ( Pamenter et al., 2018 ). Marked metabolic rate suppression is very important in hypoxia, as it reduces ATP demand to match limited ATP supply ( Buck and Pamenter, 2006 ). Hypoxic...

... -independent ATP production. Thus, it is reasonable to speculate that the degree of metabolic rate suppression and the quantity of stored fermentable fuel is strongly selected for in hypoxia-tolerant fishes; however, these assertions have not been tested in a phylogenetic comparative model. jrichard...