... respiratory coupling ratios, and better maintain membrane integrity following in vitro ischaemia or ischaemia–reperfusion treatments ( Cheng and Pamenter, 2021 ). These findings hint at a high potential for translational lessons from this species. Extreme environments are powerful drivers of novel...

.... As discussed above, the ROS generated post-ischaemia cause tissue damage associated with reoxygenation ( Murphy, 2009 ). ROS are thought to be generated from the reversal of electron flow in the ETC, where electrons are forced backwards through complex I ( Chouchani et al., 2016 ; Fig. 4 ). During anoxia...

... a significant role in the nervous system. Both EPO and its receptor are expressed throughout the brain in glial cells, neurones and endothelial cells. Hypoxia and ischaemia have been recognised as important driving forces of EPO expression in the brain. EPO has potent neuroprotective properties in vivo...

...Tom Mckean; Anna Scherzer; Han Park ABSTRACT Previous studies on the effects of ischaemia or hypoxia in ectothermic vertebrate hearts have generally used preparations that were not performing at physiological levels of pressure and flow. The conclusions that ischaemia or hypoxia are not stressful...

... hypoxia or ischaemia, glutamate transporters can run backwards, releasing glutamate into the extracellular space, triggering the death of neurones and thus causing mental and physical handicap. The rate of glutamate release by this process is slowed by the acid pH occurring in hypoxia/ischaemia, which may...

... that the isolated perfused marmot heart would be damaged less and recover better from a bout of induced hypoxia or ischaemia than would the heart of a comparison animal, the New Zealand laboratory rabbit ( Oryctolagus cuniculus ). Isolated marmot and rabbit hearts were made hypoxic by a 30 min perfusion...