... Hibernation Oxidative damage Heart Anoxia VILLUM FONDEN http://dx.doi.org/10.13039/100008398 34435 Aarhus University Research Foundation http://dx.doi.org/10.13039/501100002739 AUFF-E-2016-9-37 Medical Research Council http://dx.doi.org/10.13039/501100007155...

.... , Ostrand , K. E. and Wahl , D. H. ( 2004 ). Energetics, predators and ration affect size-dependant growth and mortality of fish during winter . Ecology 85 , 2860 - 2871 . 10.1890/03-0329 Geiser , F. ( 2016 ). Conserving energy during hibernation . J. Exp. Biol. 219...

...Madeleine S. Junkins; Sviatoslav N. Bagriantsev; Elena O. Gracheva ABSTRACT Hibernators thrive under harsh environmental conditions instead of initiating canonical behavioral and physiological responses to promote survival. Although the physiological changes that occur during hibernation have been...

...Birgitte S. Jensen; Angela Fago ABSTRACT Hibernation is a powerful response of a number of mammalian species to reduce energy during the cold winter season, when food is scarce. Mammalian hibernators survive winter by spending most of the time in a state of torpor, where basal metabolic rate...

...Heiko T. Jansen; Brandon Evans Hutzenbiler; Hannah R. Hapner; Madeline L. McPhee; Anthony M. Carnahan; Joanna L. Kelley; Michael W. Saxton; Charles T. Robbins ABSTRACT Hibernation is characterized by depression of many physiological processes. To determine if this state is reversible in a non-food...

...Shen-Hui Xu; Wei-Wei Fu; Jie Zhang; Hui-Ping Wang; Kai Dang; Hui Chang; Yun-Fang Gao ABSTRACT We previously showed that different skeletal muscles in Daurian ground squirrels ( Spermophilus dauricus ) possess different antioxidant strategies during hibernation; however, the reason for these varied...

.... Here, we propose that induced pluripotent stem cells (iPSCs) from unconventional model organisms may retain certain species-specific features that can consequently be investigated in depth in vitro ; we use hibernating mammals as an example. Many species (including ground squirrels, bats and bears) can...

... of mammalian hibernation. In animals housed at constant ambient temperatures (5°C or 25°C, 12 h:12 h light:dark photoperiod), the volume of this depot increased in the autumn and decreased in the spring, suggesting an endogenous circannual pattern. Water-fat MRI revealed that throughout the year this depot...

...Amanda D. V. MacCannell; Kevin J. Sinclair; Charles A. McKenzie; James F. Staples ABSTRACT Obligate hibernators express circannual patterns of body mass and hibernation, which persist under constant laboratory conditions. Brown adipose tissue (BAT) is important for thermogenesis during arousals...

...Mallory A. Ballinger; Matthew T. Andrews; Raul K. Suarez; Hans H. Hoppeler ABSTRACT Brown adipose tissue (BAT) is a unique thermogenic tissue in mammals that rapidly produces heat via nonshivering thermogenesis. Small mammalian hibernators have evolved the greatest capacity for BAT because they use...

...Amanda D. V. MacCannell; Ethan C. Jackson; Katherine E. Mathers; James F. Staples ABSTRACT We used electrocardiogram (ECG) telemeters to measure the heart rate of hibernating Ictidomys tridecemlineatus (thirteen-lined ground squirrel). An increase in heart rate from 2.2 to 5 beats min –1 accurately...

...Elisabeth Rosner; Christian C. Voigt ABSTRACT Mammals fuel hibernation by oxidizing saturated and unsaturated fatty acids from triacylglycerols in adipocytes, yet the relative importance of these two categories as an oxidative fuel may change during hibernation. We studied the selective use...

...Shannon E. Currie; Clare Stawski; Fritz Geiser ABSTRACT Many hibernating animals thermoregulate during torpor and defend their body temperature ( T b ) near 0°C by an increase in metabolic rate. Above a critical temperature ( T crit ), animals usually thermoconform. We investigated...

...Steven J. Swoap; Gerhard Körtner; Fritz Geiser ABSTRACT The eastern pygmy possum ( Cercartetus nanus ) is a small marsupial that can express spontaneous short bouts of torpor, as well as multi-day bouts of deep hibernation. To examine heart rate ( f H ) control at various stages of torpor...

...Jordan Balaban; Emanuel Azizi ABSTRACT Extended periods of skeletal muscle disuse can cause a significant loss of contractile proteins, which compromises the ability to generate force, mechanical work or power, thus compromising locomotor performance. Several hibernating organisms can resist muscle...

... , 1468 - 1486 . 10.1002/jbmr.141 Donahue , S. W. , Vaughan , M. R. , Demers , L. M. and Donahue , H. J. ( 2003a ). Bone formation is not impaired by hibernation (disuse) in black bears Ursus americanus . J. Exp. Biol.   206 , 4233 - 4239 . 10.1242/jeb.00671 Donahue...

... respiratory motor processes following cold-submergence. Unlike mammalian hibernators with unloaded limb muscles and inactive locomotor systems, respiratory mechanics of frogs counterintuitively allow for ventilatory maneuvers when submerged. Thus, we hypothesized that bullfrogs generate respiratory motor...

... evaluated some features of the clotting cascade of black bears, providing novel insights into the underlying mechanisms they evoke for embolic protection during hibernation. We measured activated clotting time, prothrombin time and activated partial thromboplastin time during early denning (December), late...

... of disuse and reduced mechanical loading, such as hibernating mammals and aestivating frogs, consistently exhibit limited or no change in musculoskeletal performance. What factors modulate skeletal muscle and bone mass, and what physiological and molecular mechanisms protect against losses of muscle...

.... ( 2004 ). Overwintering in tegu lizards . In Life in the Cold: Evolution, Mechanisms, Adaptation, and Application, Twelfth International Hibernation Symposium (ed. B. M.   Barnes and H. V.   Carey ), pp. 339 - 348 . Fairbanks, AK : Institute of Artic Biology . Bagshaw , R. J...