... acetyl-CoA carboxylase (ACC1), glycogen synthase (GS) and glucose transporters (GLUTs) 1 and 4. We found that in hypoxic naked mole-rats (1) metabolic rate decreased ∼80% and fuel use switched to carbohydrates, and that (2) levels of activated phosphorylated AMPK and GS, and GLUT4 expression were...

...Joshua Chia-Hsi Chang; Su-Mei Wu; Yung-Che Tseng; Yi-Chun Lee; Otto Baba; Pung-Pung Hwang SUMMARY Glucose, which plays a central role in providing energy for metabolism, is primarily stored as glycogen. The synthesis and degradation of glycogen are mainly initialized by glycogen synthase (GS...

..., and this occurred to a large extent at the expense of net carbon sources other than lactate, with these carbon sources accounting for at least 36–65%of the glycogen deposited. The sustained dephosphorylation-mediated activation of glycogen synthase, but not the changes in glucose 6-phosphate levels, most probably...

... exercise(time 0), half of the metyrapone-treated fish received a single injection of cortisol, to mimic the post-exercise rise usually observed. Muscle glycogen and the relative activities of glycogen phosphorylase a (Phos a ) and glycogen synthase I (GSase I ), regulatory enzymes for glycogen resynthesis...