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Keywords: glutamine synthetase
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Journal Articles
J Exp Biol (2016) 219 (20): 3218–3226.
Published: 15 October 2016
... was insensitive to amiloride (0.1 mmol l −1 ) or to a 10-fold elevation in seawater K + concentration (to 100 mmol l −1 ), suggesting that the mechanism does not directly involve Na + or K + transporters, but was inhibited by blockade of glutamine synthetase, the enzyme that traps ammonia-N to fuel the ornithine...
Includes: Supplementary data
Journal Articles
J Exp Biol (2013) 216 (21): 4025–4037.
Published: 1 November 2013
... exposed to HEA in a time-series analysis [500 μmol l −1 (NH 4 ) 2 SO 4 ; 15, 30, 45 and 60 min], as well as in a methionine sulfoxamine (MSOX) pre-injection experiment [to inhibit glutamine synthetase (GSase)]. These correlations consistently suggest that brain [T Amm ] is involved in the hyperventilatory...
Journal Articles
J Exp Biol (2012) 215 (2): 314–323.
Published: 15 January 2012
... decrease branchial ammonia excretion and become ureotelic. The objective of this study was to determine the influences of cortisol and ammonia on ammonia excretion relative to expression of Rhesus (Rh) glycoproteins and the ammonia-fixing enzyme, glutamine synthetase (GS). In vivo infusions...
Includes: Supplementary data
Journal Articles
J Exp Biol (2012) 215 (2): 301–313.
Published: 15 January 2012
... the movement of NH 3 across cell membranes. This study examines the effects of crowding and feeding on ammonia excretion in gulf toadfish ( Opsanus beta ) within the context of Rh glycoproteins and the ammonia-fixing enzyme, glutamine synthetase (GS). Four Rh isoforms (Rhag, Rhbg, Rhcg1 and Rhcg2) were...
Includes: Supplementary data
Journal Articles
J Exp Biol (2009) 212 (23): 3828–3836.
Published: 1 December 2009
...Y. K. Ip; A. M. Loong; B. Ching; G. H. Y. Tham; W. P. Wong; S. F. Chew SUMMARY This study aimed to examine whether the stenohaline freshwater stingray, Potamotrygon motoro , which lacks a functional ornithine—urea cycle, would up-regulate glutamine synthetase (GS) activity and protein abundance...
Journal Articles
J Exp Biol (2009) 212 (15): 2394–2402.
Published: 1 August 2009
... cycle (O–UC) enzyme activity and mRNA expression,we subjected toadfish to two-day and seven-day crowding regimes. Plasma cortisol levels were measured and liver tissue was assayed for ammonia and urea concentrations. Liver glutamine synthetase (GS), carbamoyl phosphate synthetase III (CPS), ornithine...
Journal Articles
J Exp Biol (2009) 212 (9): 1248–1258.
Published: 1 May 2009
..., respectively, of fish exposed to 25‰ water. There were significant increases in glutamine synthetase(GS) activity in muscle and liver of these fish. In addition, exposure to 25‰ water for 4 days led to significant increases in GS protein abundance in both muscle and liver, indicating that increases...
Journal Articles
J Exp Biol (2005) 208 (10): 1993–2004.
Published: 15 May 2005
... and/or glutamine in their brains, and if acute ammonia intoxication could be prevented by the administration of methionine sulfoximine [MSO; an inhibitor of glutamine synthetase (GS)] or MK801 [an antagonist of n -methyl d -aspartate type glutamate (NMDA) receptors]. For P. schlosseri and B. boddaerti exposed...
Journal Articles
J Exp Biol (2004) 207 (26): 4605–4614.
Published: 15 December 2004
..., after exposure to air for 17 days, there were significant increases in ammonia content in all these tissues in P. expansa , accompanied by significant increases in glutamine content (2.9-, 2.5-, 4.5- and 3.4-fold,respectively). Simultaneously, there were significant increases in glutamine synthetase...
Journal Articles
J Exp Biol (2003) 206 (20): 3615–3624.
Published: 15 October 2003
... Mus musculus or as in other African lungfish reported elsewhere. However,similar to other African lungfish and tetrapods, hepatic arginase of P. dolloi is present mainly in the cytosol. Glutamine synthetase activity is present in both the mitochondrial and cytosolic fractions of the liver of P. dolloi...
Journal Articles
J Exp Biol (2003) 206 (14): 2473–2486.
Published: 15 July 2003
... exposure. Instead, ammonia produced through amino acid catabolism was detoxified to glutamine, leading to the accumulation of glutamine in the body during the first 72 h of aerial exposure. Complimenting the increased glutamine formation was a significant increase in glutamine synthetase activity...
Journal Articles
J Exp Biol (2003) 206 (9): 1523–1533.
Published: 1 May 2003
...Patrick J. Walsh; Gregory D. Mayer; Mónica Medina; Matthew L. Bernstein; John F. Barimo; Thomas P. Mommsen SUMMARY We characterized the expression of the nitrogen metabolism enzyme glutamine synthetase [GSase; L-glutamate: ammonia ligase (ADP-forming), E.C.] in tissues of the gulf toadfish...
Journal Articles
J Exp Biol (2002) 205 (14): 2053–2065.
Published: 15 July 2002
... glutamine,primarily in the muscle, accompanied by an increase in glutamine synthetase(GSase) activity in liver. The aim of the present study was to assess the effect on GSase expression in various tissues of exposure of B. sinensis to exogenous ammonia. Exogenous ammonia increases internal ammonia...
Journal Articles
J Exp Biol (2001) 204 (12): 2145–2154.
Published: 15 June 2001
... that analyses of enzyme activities and metabolite levels in fish embryos with a relatively large yolk mass (e.g. salmonids) requires the careful separation of the yolk from the embryonic tissues. Fig. 1. Activities of glutamine synthetase (GSase), ornithine transcarbamoylase (OTCase), arginase...
Journal Articles
J Exp Biol (1991) 156 (1): 407–418.
Published: 1 March 1991
... activities. Compared with lower-density cells, these hepatocytes had higher activities of two cytosolic enzymes, malate dehydrogenase and glutathione-S-transferase. There was no distinct distribution pattern for alanine aminotransferase and glutamine synthetase. Despite generally lower oxidative enzyme...