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J Exp Biol (2004) 207 (10): 1625–1632.
Published: 15 April 2004
... electron microscopic studies. Generally receptor sequestration follows its desensitization, which is initiated by receptor phosphorylation by G-protein-coupled receptor kinase. We cloned and sequenced the gene fragment of 407 nucleotides homologous to theβ-adrenergic receptor kinase (βARK): its deduced...
J Exp Biol (2004) 207 (3): 411–416.
Published: 22 January 2004
... role in venom production. This receptor had relatively low sensitivity to noradrenaline (pD 2 =4.77±0.09, N =7)and to phenylephrine (pD 2 =3.77±0.06, N =11). The receptor became desensitized just after venom extraction (pD 2 to phenylephrine fell to 3.27±0.02, N =6) and the sensitivity remained low...
J Exp Biol (2003) 206 (3): 627–636.
Published: 1 February 2003
... desensitization. Either this represents a unique new class of ATP receptors,in which PPNDS is an agonist instead of an antagonist, or PPNDS (and other drugs like it) may actually be an agonist in many other cell types in which prolonged exposure is necessary for inhibition. * Author for correspondence (e...
J Exp Biol (1999) 202 (15): 2091–2102.
Published: 1 August 1999
... or aristolochic acid. Our results revealed (1) that dietary exposure to caffeine desensitized the bitter-sensitive taste cell to caffeine, whereas dietary exposure to salicin or aristolochic acid did not desensitize the same taste cell to salicin or to aristolochic acid; (2) that dietary exposure to caffeine...
J Exp Biol (1999) 202 (4): 407–416.
Published: 15 February 1999
... of this response may be mediated via functional surface receptors that show specific desensitization during adaptation. While ATP is a potent agonist for many P2 receptors, the non-hydrolyzable analogs α-β-methylene ATP and β-γ-methylene ATP are often more potent in tissue studies ( Abbracchio et al., 1993...
J Exp Biol (1996) 199 (2): 415–426.
Published: 1 February 1996
..., the antiporter is deactivated prior to restoration of the normal control volume, leaving cell volume regulation notably defective. The trout red cell antiporter, which is desensitized and enters a refractory state following hormonal activation, is only deactivated (it can be reversibly reactivated) after...
J Exp Biol (1993) 184 (1): 145–159.
Published: 1 November 1993
... with activation of phosphoinositidase-C-linked receptors, is a feedback activator and amplifier of phosphoinositide hydrolysis, (b) that rapid desensitization, possibly associated with receptor phosphorylation, regulates phosphoinositidase-C-linked receptors, (c) that receptor internalization can mediate...
J Exp Biol (1988) 140 (1): 535–548.
Published: 1 November 1988
... of desensitization of the glutamate response was studied using a double-pulse method. The initial decrease in the ratio, PSP 2 /PSP 1 , is followed by a slower time-dependent recovery of the postsynaptic response with a time constant of 8·5 s. Prolonged perfusion of the squid giant synapse with concanavalin A failed...