...Xuan Huang; Adriano Senatore; Taylor F. Dawson; Quyen Quan; John David Spafford SUMMARY Voltage-gated calcium channels in the Ca v 2 channel class are regulators of synaptic transmission and are highly modified by transmitter inputs that activate synaptic G-protein-coupled receptors (GPCRs...

... voltage-gated currents, conducted by a T-type calcium channel CCA-1, an L-type calcium channel EGL-19 and a potassium channel EXP-2. We show that CCA-1 exhibits T-type calcium channel properties: activation at -40 mV and rapid inactivation. Our results suggest that CCA-1's role is to accelerate the action...

...Katherine A. Steger; Boris B. Shtonda; Colin Thacker; Terrance P. Snutch; Leon Avery SUMMARY Low threshold-activated or T-type calcium channels are postulated to mediate a variety of bursting and rhythmic electrical firing events. However,T-type channels' exact physiological contributions have been...

..., exhibited an apparent 1:1 transport stoichiometry and possessed a minimal divalent cation specificity. Calcium transport at this epithelial pole occurred by the combination of a Ca 2+ /Na + antiporter, an ATP-dependent Ca 2+ -ATPase and a verapamil-sensitive calcium channel. These crustacean brush-border...

...+ channel blockers nicardipine and ω -conotoxin, suggesting that in this neurosecretory system both L-and N-type calcium channels play a major role in stimulus–secretion coupling. Depolarization of isolated nerve endings using a fast-flow perifusion system showed that there was no difference...

.... ( 1983 ). Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialyzed heart cells . Nature 302 , 790 – 794 . 10.1038/302790a0 Macdonald , J. F. and Schneiderman , J. H. ( 1983 ). Actions of verapamil on the excitability of cultured...

... potential duration. The plateau amplitude was markedly increased when the external Ca 2+ concentration was increased to 60 mmol I −1 and it was inhibited by the addition of inorganic calcium channel blockers such as Mn 2+ and Cd 2+ . These observations suggest that inward Ca 2+ currents cause the sustained...

...-channel and whole-cell calcium or barium currents in single smooth muscle cells of rabbit ear artery and the effects of noradrenaline . J. Physiol., Lond , (in press) . Armstrong , C. M. & Matteson , D. R. ( 1985 ). Two distinct populations of calcium channels in a clonal line...