... KN-93. Peptide-induced contractions in the mutants of the phospholipase C-β ( PLC β) gene ( norpA larvae) and in IP 3 receptor mutants were similar to contractions elicited in control larvae. The peptide failed to increase cAMP and cGMP levels in Drosophila body wall muscles. Peptide-induced...

...K. Dawson-Scully; D. Bukvic; M. Chakaborty-Chatterjee; R. Ferreira; S. L. Milton; M. B. Sokolowski SUMMARY In this study we identify a cGMP-dependent protein kinase (PKG) cascade as a biochemical pathway critical for controlling low-oxygen tolerance in the adult fruit fly, Drosophila melanogaster...

... monophosphate (cAMP) whereas it significantly reduced the intracellular concentration of 3′,5′-cyclic guanosine monophosphate (cGMP). The reduction of cGMP was not observed in the presence of the PKC inhibitor BIM-1. 8-Bromo-cGMP, a membrane-permeable cGMP analogue, reduced the potentiating effect of proctolin...

... guanosine monophosphate (cGMP) from 2.9 μmol l –1 (control) to 7.4 μmol l –1 . A peritubular [cGMP] of 20 μmol l –1 duplicated the antidiuretic effects of Tenmo ADFa without inducing electrophysiological effects. In contrast, 500 μmol l –1 cGMP significantly depolarized V bl , hyperpolarized V t...

...., Werner, M., Heppenstall, P. A., Henning, M., More,M. I., Kuhbandner, S., Lewin, G. R., Hofmann, F., Feil, R. and Rathjen,F. G. ( 2002 ). cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons. J. Cell Biol. 159 , 489 -498. Shah, S. and Hyde, D. R...

... of Biologists Limited 2003 2003 cGMP guanylyl cyclase nitric oxide protein dimerization tobacco hornworm Manduca sexta Soluble guanylyl cyclases have classically been described as obligate heterodimers that form the principal receptor for nitric oxide (NO)( Lucas et al., 2000 ). Two recent...

.... Ecdysis of intact larvae is associated with the central release of eclosion hormone (EH) and elevation of cyclic 3′,5′-guanosine monophosphate (cGMP) in the ventral nerve cord. However, injection of ETH into isolated abdomens induces cGMP elevation and ecdysis behaviour without a detectable release of EH...

... concentration of eclosion hormone needed to evoke release of ETH is approximately 3 pmol l −1 . Eclosion hormone also induces elevation of cyclic GMP, but not cAMP, concentration in epitracheal glands at concentrations similar to those causing release of ETH. Both cGMP and 8-Br-cGMP mimic the secretory action...