..., immunoreactive neurons were observed mostly in the medulla oblongata, including the reticular formation, glossopharyngeal-vagal motor complex, commissural nucleus of Cajal, and area postrema (AP). Trypan Blue, which binds serum albumin and does not cross the blood–brain barrier, was injected peripherally...

...P. J. S. Smith; A. Shipley ABSTRACT One notable characteristic of the insect and vertebrate central nervous system is the presence of a clearly defined blood-brain barrier. In the insect this barrier is made up of the perineurial glial cells, and shows a heterogeneity in structure and possibly...

...P. K. Schofield ABSTRACT In an abdominal ganglion of the American cockroach, Periplaneta americana , electrophysiological characteristics of the perineurium, the glial layer that forms the insect blood-brain barrier, were investigated by microelectrode recording. The potential across the barrier...

... the endothelial blood-brain barrier (BBB) and some glial cells, notably the astrocytes, seem to be programmed to act as most efficient and complex partners for antigen-specific T-lymphocytes. We used myelin basic protein (MBP) specific permanent rat T-lymphocyte lines as probes to assess the immune status...

... conditions, the blood-brain barrier was found to be suitably efficient in restricting the influx of K + and thereby allowing normal neural activity. At an external K + concentration of 100 mmol I −1 , however, the system was unable to maintain a sufficiently low extracellular K + concentration and neuronal...

...P. K. Schofield; J. E. Treherne ABSTRACT Octopaminergic sensitivity of the glia that form the blood-brain barrier of the cockroach was examined using microelectrode recordings of the potential developed across this barrier layer, the perineurium. Exposure to 10 −4 moll −1 DL-octopamine had...

...P. K. Schofield; L. S. Swales; J. E. Treherne ABSTRACT The blood-brain barrier of the insect nervous system is thought to be formed by the neuroglia. It is associated with a positive interstitial potential relative to the bathing medium (‘sheath’ potential), and with positive changes in potential...

...P. K. Schofield; J. E. Treherne ABSTRACT The perineurium was found to form the principal barrier to diffusion across the blood-brain barrier system of the cockroach, Periplaneta americana , since the resistance across this layer was much greater than that across the underlying neuroglia...

...P. K. Schofield; L. S. Swales; J. E. Treherne ABSTRACT Brief exposure of central nervous connectives of the cockroach, Periplaneta americana , to 3 M-urea, a treatment known to increase the leak of cations across the blood-brain barrier system, caused a reduction in the resistance and potential...