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Keywords: alphastat
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Journal Articles
J Exp Biol (2018) 221 (1): jeb168955.
Published: 4 January 2018
...Stanley S. Hillman; Michael S. Hedrick ABSTRACT Body temperature increases in ectothermic vertebrates characteristically lead to both increases in arterial P CO 2 ( P a CO 2 ) and declines in resting arterial pH (pHa) of about 0.017 pH units per 1°C increase in temperature. This ‘alphastat’ pH...
Journal Articles
J Exp Biol (2002) 205 (23): 3587–3600.
Published: 1 December 2002
...Richard F. Burton SUMMARY The `imidazole alphastat hypothesis' states that intracellular and extracellular pH, partly via buffering by imidazole groups, change with temperature in a way that keeps imidazole and protein ionization constant, thus maintaining cell function and minimizing shifts...
Journal Articles
J Exp Biol (1985) 114 (1): 37–51.
Published: 1 January 1985
... and for constant dissociation of imidazole. The changes of cerebrospinal fluid pH with temperature, calculated from the mean arterial values, were even smaller [ΔpH/Δt csf = −0·008). It is concluded that the observed temperature dependence of the acid-base status is not in agreement with the alphastat hypothesis...