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Keywords: aging
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Journal Articles
JEB: 100 years of discovery
J Exp Biol (2023) 226 (3): jeb244844.
Published: 31 January 2023
.... , Castellucci , V. F. , Koester , J. and Chen , M. ( 1983 ). Behavioral changes in aging Aplysia : a model system for studying the cellular basis of age-impaired learning, memory, and arousal . Behav. Neural Biol. 38 , 70 - 81 . 10.1016/S0163-1047(83)90399-0 Bailey , C. H...
Journal Articles
J Exp Biol (2022) 225 (12): jeb244282.
Published: 22 June 2022
... lysosomes, a non-canonical lysosome morphology that forms in the gut of hermaphrodites when food is limited or as animals age. We found that constitutive induction of gut tubular lysosomes in males results from self-imposed dietary restriction through DAF-7/TGFβ, which promotes exploratory behavior...
Includes: Supplementary data
Journal Articles
J Exp Biol (2022) 225 (1): jeb243532.
Published: 6 January 2022
...Marina R. Sartori; Claudia D. C. Navarro; Roger F. Castilho; Anibal E. Vercesi ABSTRACT The interaction between supraphysiological cytosolic Ca 2+ levels and mitochondrial redox imbalance mediates the mitochondrial permeability transition (MPT). The MPT is involved in cell death, diseases and aging...
Includes: Supplementary data
Journal Articles
J Exp Biol (2021) 224 (15): jeb242218.
Published: 5 August 2021
... seawater lagoons at two facilities (Dolphin Research Center and Dolphin Quest) using the doubly labeled water method. We assessed the relative effects of body mass, age and physical activity on TEE. We also examined whether TEE of bottlenose dolphins, and more generally of marine mammals, differs from...
Includes: Supplementary data
Journal Articles
J Exp Biol (2021) 224 (5): jeb237073.
Published: 1 March 2021
... animals in their ecological contexts. Fifteen healthy young adults ( N =6 females and N =9 males, age 19–30 years; height 1.76±0.18 m, mass 72.5±7.5 kg, means±s.d.) with no history of neurological, vestibular or movement disorders or other problems that could alter typical walking patterns participated...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (12): jeb223057.
Published: 17 June 2020
...Jessica M. Judson; Dawn M. Reding; Anne M. Bronikowski ABSTRACT Immunosenescence is a well-known phenomenon in mammal systems, but its relevance in other long-lived vertebrates is less understood. Further, the influence of age and reproductive effort on immune function in long-lived species can...
Journal Articles
J Exp Biol (2020) 223 (Suppl_1): jeb209296.
Published: 1 February 2020
... observed even among somewhat closely related species; for example, in the laboratory, wild-derived strains of the common house mouse have a maximum observed lifespan of approximately 6 years, while a similarly sized rodent, the naked mole rat, can live for over 30 years. Comparative biology of aging across...
Journal Articles
J Exp Biol (2019) 222 (18): jeb211185.
Published: 19 September 2019
...Ana Gabriela Jimenez; Erin S. O'Connor; Kyle H. Elliott ABSTRACT In birds, many physiological parameters appear to remain constant with increasing age, showing no deterioration until ‘catastrophic’ mortality sets in. Given their high whole-organism metabolic rate and the importance of flight...
Journal Articles
J Exp Biol (2019) 222 (12): jeb200246.
Published: 25 June 2019
... and accelerated aging. We contrasted markers of oxidative damage with antioxidant profiles across age and sex for propulsive (longissismus dorsi) and maneuvering (pectoralis) muscles of Weddell seals to determine whether previously observed morphological senescence is associated with oxidative stress...
Journal Articles
J Exp Biol (2019) 222 (7): jeb199364.
Published: 9 April 2019
...Stephanie P. Kelly; Ken Dawson-Scully ABSTRACT The common fruit fly, Drosophila melanogaster , is a well-characterized model for neurological disorders and is widely used to investigate the biology of aging, stress tolerance and pleiotropy. The foraging ( for ) gene encodes a cGMP-dependent protein...
Journal Articles
J Exp Biol (2019) 222 (Suppl_1): jeb187252.
Published: 6 February 2019
... the specifics of using VR in spatial navigation research across species, we outline several challenges when investigating age-related deficits in spatial navigation with the help of VR. In addition, we discuss ways to reduce their impact, together with the possibilities VR offers for improving navigational...
Journal Articles
J Exp Biol (2017) 220 (6): 1008–1018.
Published: 15 March 2017
...Gaspar Epro; Andreas Mierau; Jonas Doerner; Julian A. Luetkens; Lukas Scheef; Guido M. Kukuk; Henning Boecker; Constantinos N. Maganaris; Gert-Peter Brüggemann; Kiros Karamanidis ABSTRACT The aging musculoskeletal system experiences a general decline in structure and function, characterized...
Journal Articles
J Exp Biol (2016) 219 (16): 2469–2474.
Published: 15 August 2016
...Franz Hoelzl; Jessica S. Cornils; Steve Smith; Yoshan Moodley; Thomas Ruf ABSTRACT We studied the impact of hibernation and food supply on relative telomere length (RTL), an indicator for aging and somatic maintenance, in free-living edible dormice. Small hibernators such as dormice have ∼50...
Journal Articles
J Exp Biol (2016) 219 (7): 998–1003.
Published: 1 April 2016
... of both healthy young rats, and old rats where the interaction between contractile and connective tissue properties was assumed to be disrupted. Muscle fiber and aponeurosis stiffness increased with age ( P <0.05) from 19.1±5.0 kPa and 188.5±24.2 MPa, respectively, in young rats to 39.1±4.2 kPa...
Journal Articles
J Exp Biol (2015) 218 (1): 59–70.
Published: 1 January 2015
... a crucial role in aging and cancer. Reductions in caloric intake have been shown to increase both the life- and health-span in a variety of animal models. Moreover, restriction of glucose has been demonstrated to decrease the incidence of age-related diseases such as cancer and diabetes. A diet rich...
Journal Articles
J Exp Biol (2014) 217 (1): 109–118.
Published: 1 January 2014
...Lifen Wang; Jason Karpac; Heinrich Jasper; Shireen A. Davies; Julian A. T. Dow; Ken Lukowiak Aging is characterized by a widespread loss of homeostasis in biological systems. An important part of this decline is caused by age-related deregulation of regulatory processes that coordinate cellular...
Journal Articles
J Exp Biol (2014) 217 (1): 137–143.
Published: 1 January 2014
... that a progressive decline of the efficiency of stress response pathways occurs with aging. In this context, a correct proteostasis is essential for the functionality of the cell, and its dysfunction has been associated with protein aggregation and age-related degenerative diseases. Complex response mechanisms have...
Journal Articles
J Exp Biol (2013) 216 (2): 208–217.
Published: 15 January 2013
.... * These authors contributed equally to this work † Author for correspondence ( sluckhart@ucdavis.edu ) 2 8 2012 24 9 2012 © 2013. 2013 insulin insulin-like growth factor mosquito aging signal transduction A control and two treatment groups of A. stephensi females ( N...
Journal Articles
J Exp Biol (2012) 215 (12): 2039–2050.
Published: 15 June 2012
... 9 2011 22 2 2012 © 2012. 2012 skeletal muscle mitochondria substrate oxidation aging reactive oxygen species bird Flying birds couple a long lifespan with a high metabolic rate, as well as a chronically high blood glucose concentration (∼15 mmol l –1 ) and insulin...
Journal Articles
J Exp Biol (2012) 215 (5): 814–821.
Published: 1 March 2012
... and reproductive potential. Aging is a process that results in a steady decline in survival and reproductive output, yet little is known about its effect on specific aspects of attractiveness. In this report we asked how aging impacts pheromone production and sexual attractiveness in Drosophila melanogaster...
Includes: Supplementary data