... is to maintain good proteostasis via the unfolded protein response (UPR) ( Hetz et al., 2015 ). The two primary components of the UPR are (1) the ubiquitin–proteasome system, which limits the accumulation of damaged proteins by degrading denatured non-functional proteins and preventing their accumulations from...

... cellular signalling pathways [hypoxia inducible factor (HIF), unfolded protein response (UPR) and mTOR pathways] since most of what we know comes from studies on cancerous mammalian cell lines. Arctic char were exposed to cumulative graded hypoxia trials for 3 h at four air saturation levels (100%, 50%, 30...