... retinas. ipRGCs were initially thought to be a single retinal ganglion cell population, and melanopsin was thought to activate a single, invertebrate-like G q /transient receptor potential canonical (TRPC)-based phototransduction cascade within these cells. However, in the 20 years since the discovery...

...Doron G. Hickey; Wayne I. L. Davies; Steven Hughes; Jessica Rodgers; Navamayooran Thavanesan; Robert E. MacLaren; Mark W. Hankins ABSTRACT Human opsin-based photopigments have great potential as light-sensitisers, but their requirement for phototransduction cascade-specific second messenger...

...-licence-1-1/ Editors' Choice: Reduced oxygen availability decreases retinal sensitivity and temporal resolution in marine invertebrate larvae, which may impact visual behaviors crucial to survival and increase vulnerability of species to ocean oxygen loss. Zooplankton Phototransduction...

... of Mammoth Cave, the world's largest known cave system, has been considered blind despite the presence of residual lens structures. By deep sequencing of the adult head transcriptome, we discovered the transcripts of all core members of the phototransduction protein machinery. Combined with the absence...

...Roger C. Hardie SUMMARY As in most invertebrate microvillar photoreceptors, phototransduction in Drosophila melanogaster uses a G-protein-coupled phosphoinositide pathway, whereby hydrolysis of phosphatidyl inositol 4,5-bisphosphate (PIP 2 ) by phospholipase C generates inositol 1,4,5-trisphosphate...