... polymorphism in the gene phosphoglucose isomerase ( Pgi ) was significantly associated with both MR peak and lifespan, and may have coevolved with defence mechanisms against senescence. Generalisations such as ‘live fast, die young’ may be too simple to explain the complex processes affecting ageing...

.... Allele frequencies at the enzyme locus phosphoglucose isomerase (PGI) vary across a climatic latitudinal gradient in these populations, with PGI allele 1 being most common in cooler regions and PGI allele 4 in warmer ones. PGI genotypes differ in heat and cold tolerance and in expression of a 70 kDa heat...