...-related factor 2 (Nrf2) were also measured. Turtles were acclimated at 28°C (3 weeks), then given acute cold exposure (8°C, 12 h) and finally placed in recovery (28°C, 24 h). The mRNA levels of cerebral and hepatic Nrf2 and of genes encoding downstream antioxidant enzymes did not change, whereas levels...

...Andrew M. Pickering; Trisha A. Staab; John Tower; Derek Sieburth; Kelvin J. A. Davies SUMMARY In mammalian cells, hydrogen peroxide (H 2 O 2 )-induced adaptation to oxidative stress is strongly dependent on an Nrf2 transcription factor-mediated increase in the 20S proteasome. Here, we report...

... (e.g. paracetamol). There is now an emerging literature that the adaptive response to chemical stress from endogenous and exogenous chemically reactive species, is activated and orchestrated by redox-sensitive transcription factors, which include Nrf2,AP-1, NF-kappa B and STAT-1. Such a response...