...Marie N. Hansen; Jon O. Lundberg; Mariacristina Filice; Angela Fago; Nanna M. G. Christensen; Frank B. Jensen ABSTRACT In mammals, treatment with low doses of nitrite has a cytoprotective effect in ischemia/reperfusion events, as a result of nitric oxide formation and S -nitrosation of proteins...

...Frank B. Jensen; Lucie Gerber; Marie N. Hansen; Steffen S. Madsen ABSTRACT Nitrite secures essential nitric oxide (NO) bioavailability in hypoxia at low endogenous concentrations, whereas it becomes toxic at high concentrations. We exposed brown trout to normoxic and hypoxic water in the absence...

...Frank B. Jensen; Marie N. Hansen; Gabriella Montesanti; Tobias Wang Moderate elevations of nitrite and nitric oxide (NO) protect mammalian tissues against ischemia (anoxia)-reperfusion damage by inhibiting mitochondrial electron transport complexes and reducing the formation of reactive oxygen...

... defence. To understand whether nitric oxide (NO), a major regulator of vasodilatation and oxygen consumption, may be involved in the adaptive response of Trachemys to anoxia, we measured NO metabolites (nitrite, S- nitroso, Fe-nitrosyl and N- nitroso compounds) in the plasma and red blood cells of venous...

... -nitrosylation of proteins – and it is metabolized to nitrite and nitrate. Nitrite is used as a marker for NOS activity but it is also a NO donor that can be activated by various cellular proteins under hypoxic conditions. Here, we report the first systematic study of NO metabolites (nitrite, nitrate, S -nitroso...

... oxide nitrite Interactions of myoglobin (Mb) and nitrogen oxides (NO x ) have been used for centuries as a means of meat preservation even though there was no concrete knowledge of the underlying biochemical processes. Although the origin of food curing is lost in history, it seems clear...

... a control system that preserves mitochondrial respiration. In addition, myoglobin may also protect the heart against reactive oxygen species (ROS), and, under hypoxic conditions, deoxygenated myoglobin is able to reduce nitrite to NO • leading to a downregulation of the cardiac energy status...

...-dependent release of ATP from RBCs, which stimulates production of nitric oxide (NO) and other vasodilators in the endothelium; (2) release of vasoactive NO from S -nitroso-Hb upon deoxygenation; and (3) reduction of naturally occurring nitrite to vasoactive NO by deoxygenated Hb. This Commentary inspects...

...Frank B. Jensen SUMMARY Nitrite is a potential nitric oxide (NO) donor and may have important biological functions at low concentrations. The present study tests the hypothesis that nitrite accumulation across the gills in fish will cause a massive NO production from nitrite. Zebrafish were exposed...

...F. B. Jensen; C. Agnisola SUMMARY A method for perfusion of the isolated trout heart coronary circulation with red blood cells (RBCs) was developed. The method was used to analyse the influence of RBC perfusion on myocardial O 2 supply and O 2 consumption and to test the hypothesis that nitrite...

...M. Grosell; F. B. Jensen ABSTRACT Ion transport across isolated intestinal segments from the European flounder ( Platichthys flesus ) was studied with the primary aim of evaluating the mechanisms of nitrite (NO 2 − ) uptake and HCO 3 − excretion. A double-radiolabelling technique was applied...

...Frank B. Jensen ABSTRACT Red cell function was studied in carp by a combination of in vivo and in vitro experiments with nitrite as the perturbing agent. In vivo accumulation of nitrite caused a marked increase in the red cell methaemoglobin content, and reduced the mean cellular volume. The oxygen...