... by at least two mechanisms, electroneutral exchange with Na + or active H + pumping ( Perry et al.,2003a ; Perry et al.,2003b ; Perry and Gilmour,2006 ). Available evidence suggests that electroneutral Na + /H + exchange is accomplished by NHE3 (SLC9A3), a member of the NHE (SLC9) multi-gene family...

... at the proximal end of the gut to support the Na + -dependent nutrient-absorption processes. Even more striking is that the Na + /K + -ATPase is located in the apical membrane in exactly the region of high luminal alkalinity and the hypothesis arises that it could serve as an ATP-driven Na + /H + exchanger...

... + exchanger activity were examined. Cadmium (50 μmol l –1 ) caused a significant elevation of intracellular pH (pHi) and a rise (176%) of Na influx relative to control values. The amiloride analogue, EIPA (20 nmol l –1 ), a Na + /H + exchanger blocker,together with cadmium, significantly reduced the effect...

...-adrenergic receptor (β-AR) binding characteristics,β-adrenergically stimulated RBC Na + /H + exchanger(βNHE) activity, together with β-AR and βNHE mRNA levels and plasma steroid hormone and lactate levels. These parameters were measured at approximately monthly intervals in a single population of fish held...

...Maria E. Giannakou; Julian A. T. Dow SUMMARY The NHE family of Na + /H + exchangers is believed to play an essential role in animals, but may play an additional, specialised epithelial role in insects. The pharmacological sensitivity of the Drosophila melanogaster Malpighian tubule to a range...

... not inhibit the swelling response with amiloride in the present study, earlier data on rainbow trout erythrocytes using a similar procedure ( Nikinmaa, 1982 ) and on other cell types ( Grinstein et al., 1984 ) indicate that cell swelling initiated by the activation of Na + /H + exchange and measured using...

... by the phosphatase inhibitor okadaic acid, may consist of the dephosphorylation of one of these two sites. Furthermore, Calyculin A (ClA), another specific protein phosphatase inhibitor, induces in unstimulated cells a Na + /H + exchange activity whose exchange properties are very different from those...

...A. R. Cossins; R. V. Kilbey ABSTRACT The effects of temperature upon the adrenergic Na + /H + exchange of rainbow trout erythrocytes have been studied in vitro . The initial rates of H + ejection and of increase of intracellular Na + ([Na + 1 ) in adrenergically stimulated cells were highly...