... mean metabolic rate depression increased with more severe hypoxia ( F 1.389,16.67 =29.82, P <0.0001). Similarly, hypoxia had an overall significant effect on V̇ CO 2  relative to normoxic controls ( F 3,34 =3.80, P =0.0188; Fig. 1 , blue bars) and with deeper hypoxia ( F 1.294,15.53 =16.75...

...-oxygen stress. Understanding how anoxia-tolerant organisms are able to protect themselves against DNA damage could provide important clues towards survival under metabolic rate depression and preparation for recovery to minimize damage. References Ashcroft , M. and Vousden , K. H. ( 1999...

..., by microRNAs that can rapidly and reversibly target all biological functions. Herein, we review the involvement of microRNAs in natural models of anoxia and hypoxia tolerance, with a focus on the involvement of oxygen-responsive microRNAs (OxymiRs) in coordinating the metabolic rate depression that allows...

.... Orconectes virilis Anoxia tolerance Metabolic rate depression HIF1 In the winter, the freshwaters of eastern North America become ice-locked, cutting off access to fresh nutrients, and thus rendering waters anoxic ( Bradford, 1983 ), while in the summer, warm and stagnant waters present a hypoxia...

... translation. For a hypoxia-exposed animal, energy metabolism is the combined sum of aerobic metabolism, anaerobic metabolism and metabolic rate depression. Aerobic metabolism Aerobic metabolism centers on oxidative phosphorylation, the O 2 -dependent process by which ATP is produced in the mitochondria...

... levels of glucose during freezing in the wood frog, Rana sylvatica . Antioxidants Enzyme kinetics Freezing Metabolic rate depression Phosphorylation The North American wood frog, Rana sylvatica (syn: Lithobates sylvaticus ), is able to overwinter in a remarkable fashion; it freezes...

... ) Competing interests The author declares no competing financial interests. © 2015. Published by The Company of Biologists Ltd 2015 Metabolic rate depression Hibernation Anoxia tolerance Histone control miRNA RNA-binding proteins Post-translational modification All organisms...

... 2011 © 2012. 2012 antioxidant defense metabolic rate depression regulation of gene expression reversible protein phosphorylation signal transduction pathway signaling cascade Aestivation is typically defined as a summer or dry season dormancy. The word derives from the Latin...

... of mantle cavity P O 2 ( Table 2 ). Fig. 5. Residuals of the ANCOVA model plotted over time for (A) normoxic (GB normox ) Arctica islandica ( N =8) and (B) anoxic (GB anox ) A. islandica prior to the metabolic rate depression (MRD) status [defined as partial pressure of oxygen ( P O 2 )=0...

... by dephosphorylation in a tissue-specific manner. * Author for correspondence ( chris.ramnanan@vanderbilt.edu ) 17 9 2009 © 2010. 2010 sarcoendoplasmic reticulum Ca 2+ -ATPase (SERCA) anoxia phosphorylation metabolic rate depression Trachemys scripta elegans Several species...

... in the hypometabolic state. * Author for correspondence (e-mail: kenneth_storey@carleton.ca ) 15 1 2007 © The Company of Biologists Limited 2007 2007 metabolic rate depression anoxia tolerance hibernation reversible protein phosphorylation signal transduction stress-induced gene...

... 2006 metabolic rate depression reversible phosphorylation hepatopancreas foot muscle regulation of ion pumps land snail Otala lactea The land snail Otala lactea is a native of the seasonally arid lands of the Mediterranean region. When food or water is limiting, this pulmonate...

... biological generality. Potential mechanisms involved in their stability are discussed. * e-mail: jsclegg@ucdavis.edu . 23 10 1996 © The Company of Biologists Limited 1997 Artemia franciscana brine shrimp embryo anoxia metabolic rate depression trehalose protein...

... 10 1990 © 1991 by Company of Biologists 1991 Busycon canaliculatum glycolytic enzyme binding regulatory role of pH metabolic rate depression Changes in intracellular pH are frequently linked to changes in cellular function. In particular, a significant correlation between...

... that reversible phosphorylation control over the activity state of regulatory enzymes of glycolysis is one mechanism contributing to the overall metabolic rate depression of the estivating state. 07 06 1990 © 1990 by Company of Biologists 1990 control of glycolysis metabolic rate depression...

... of protein kinases during anoxia is not mediated by pH or by common second-messenger mechanisms. Anoxia-induced metabolic rate depression is widespread throughout the animal kingdom, and the biochemical mechanisms that form the basis of this phenomenon are expressed in numerous invertebrate and vertebrate...