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Journal: Journal of Experimental Biology
J Exp Biol (2002) 205 (5): 677–685.
Published: 1 March 2002
... factor, heat-shock factor-1 (HSF1), thereby reducing the levels of free HSF1 that are available to bind to the heat-shock element, a regulatory element upstream of hsp genes. Under stress, hsps bind to denatured proteins, releasing HSF1, which can now activate hsp gene transcription. Thus, elevated...