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Keywords: CFTR
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Journal Articles
Journal Articles
J Exp Biol (2015) 218 (8): 1259–1269.
Published: 15 April 2015
... is modified to allow Na + secretion in hypersaline environments. Mummichogs ( Fundulus heteroclitus ) acclimated to hypersaline [2× seawater (2SW), 64‰] for 30 days developed invasive projections of accessory cells with an increased area of tight junctions, detected by punctate distribution of CFTR (cystic...
Journal Articles
Journal Articles
J Exp Biol (2012) 215 (4): 642–652.
Published: 15 February 2012
... greater in seawater-acclimated individuals by 40% and 200%, respectively. NKA and NKCC1 were localized on the basolateral surface and tubular network of ionocytes in both acclimation groups. Immunohistochemical labeling for the cystic fibrosis transmembrane conductance regulator (CFTR) was restricted...
Journal Articles
Journal Articles
J Exp Biol (2006) 209 (23): 4591–4596.
Published: 1 December 2006
... rainbow trout, we demonstrate that internal salt loading alone, is able to induce various elements of the seawater gill phenotype. Specifically, we show upregulation of three ion transport genes, cystic fibrosis transmembrane conductance regulator (CFTR),Na + /K + /2Cl - co-transporter (NKCC1) and Na + /K...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
J Exp Biol (2000) 203 (13): 1947–1962.
Published: 1 July 2000
...Nael A. Mccarty ABSTRACT The cystic fibrosis transmembrane conductance regulator (CFTR) protein forms a Cl − channel found in the plasma membranes of many epithelial cells, including those of the kidney, gut and conducting airways. Mutation of the gene encoding CFTR is the primary defect in cystic...
Journal Articles
J Exp Biol (1994) 196 (1): 405–418.
Published: 1 November 1994
... Cl − channel and basolateral cotransporter have enabled more detailed analyses of the mechanisms and their regulation. Not surprisingly, since hormones acting through kinases control secretion, both the Cl − channel, which is the shark counterpart of the CFTR (Cystic Fibrosis Transmembrane...