... days), and (3) cystic fibrosis transmembrane conductance regulator ( cftr ) mRNA was elevated in accordance with established changes in transcellular Cl − movement. Changes in mRNA encoding cldn-10c and -10f appeared linked, consistent with the tandem repeat locus in the Fundulus genome, whereas mRNA...

... is modified to allow Na + secretion in hypersaline environments. Mummichogs ( Fundulus heteroclitus ) acclimated to hypersaline [2× seawater (2SW), 64‰] for 30 days developed invasive projections of accessory cells with an increased area of tight junctions, detected by punctate distribution of CFTR (cystic...

...Shujun Fan; Natalie Harfoot; Ray C. Bartolo; A. Grant Butt SUMMARY The cystic fibrosis transmembrane conductance regulator (CFTR) is central to anion secretion in both the possum and eutherian small intestine. Here, we investigated its role in the possum proximal colon, which has novel transport...

... greater in seawater-acclimated individuals by 40% and 200%, respectively. NKA and NKCC1 were localized on the basolateral surface and tubular network of ionocytes in both acclimation groups. Immunohistochemical labeling for the cystic fibrosis transmembrane conductance regulator (CFTR) was restricted...

... and the cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane. However, in the possum ileum, NKCC1 expression is low and secretagogues stimulate electrogenic HCO 3 – secretion driven by a basolateral NaHCO 3 cotransporter (pNBCe1). Here we investigated whether electrogenic anion...

... rainbow trout, we demonstrate that internal salt loading alone, is able to induce various elements of the seawater gill phenotype. Specifically, we show upregulation of three ion transport genes, cystic fibrosis transmembrane conductance regulator (CFTR),Na + /K + /2Cl - co-transporter (NKCC1) and Na + /K...

... ion absorption from food when it is present in the gut. Modulation of net ion flux occurred without changes in mRNA levels of many ion transporters (Na + /K + -ATPase α 1a ,carbonic anhydrase 2, CFTR Cl – channel,Na + /K + /2Cl – cotransporter 2, and the signalling protein 14-3-3a), and before...

...Stephen D. McCormick; Kristina Sundell; Björn Thrandur Björnsson; Christopher L. Brown; Junya Hiroi SUMMARY Na + /K + -ATPase,Na + /K + /2Cl - cotransporter (NKCC) and cystic fibrosis transmembrane conductance regulator (CFTR) are the three major transport proteins thought to be involved...