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Keywords: Atrophy
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Journal Articles
J Exp Biol (2021) 224 (21): jeb242698.
Published: 4 November 2021
...David S. Brooks; Kumar Vishal; Simranjot Bawa; Adrienne Alder; Erika R. Geisbrecht ABSTRACT Muscle atrophy, or a decline in muscle protein mass, is a significant problem in the aging population and in numerous disease states. Unraveling molecular signals that trigger and promote atrophy may lead...
Includes: Supplementary data
Journal Articles
J Exp Biol (2018) 221 (8): jeb176156.
Published: 19 April 2018
... their gastrointestinal (GI) mass, which allows a substantial energy economy. This strategy, however, implies that the first post-dormancy digestion would be more costly than subsequent feeding episodes as a result of GI atrophy. To address this, we determined the postprandial metabolic response (SDA) of the first (M1...
Journal Articles
J Exp Biol (2016) 219 (2): 235–242.
Published: 1 January 2016
..., previously untrained fibres recruit myonuclei from activated satellite cells before hypertrophic growth. Even if subsequently subjected to grave atrophy, the higher number of myonuclei is retained, and the myonuclei seem to be protected against the elevated apoptotic activity observed in atrophying muscle...
Journal Articles
J Exp Biol (2016) 219 (2): 226–234.
Published: 1 January 2016
...Clark J. Cotton; Stan L. Lindstedt; Hans H. Hoppeler ABSTRACT Hibernation is characterized by prolonged periods of inactivity with concomitantly low nutrient intake, conditions that would typically result in muscle atrophy combined with a loss of oxidative fibers. Yet, hibernators consistently...
Journal Articles
J Exp Biol (2016) 219 (2): 276–284.
Published: 1 January 2016
..., and in ageing, have been obtained by the use of ultrasonography; these have led to the identification of clinical biomarkers of disuse atrophy and sarcopenia. Recent evidence also shows that the pattern of muscle hypertrophy in response to chronic loading is contraction-mode dependent (eccentric versus...
Journal Articles
J Exp Biol (2012) 215 (12): 2081–2087.
Published: 15 June 2012
...David C. Lin; John D. Hershey; John S. Mattoon; Charles T. Robbins SUMMARY Hibernating bears retain most of their skeletal muscle strength despite drastically reduced weight-bearing activity. Regular neural activation of muscles is a potential mechanism by which muscle atrophy could be limited...
Journal Articles
J Exp Biol (2011) 214 (17): 2896–2902.
Published: 1 September 2011
... of daily torpor had no effect on the rate at which stress or work was produced in soleus and EDL muscles in Djungarian hamsters; however, torpor did increase the stress and power produced by the soleus. atrophy fatigue resistance torpor mechanics stress © 2011. 2011 3 6 2011...
Journal Articles
J Exp Biol (2003) 206 (3): 561–575.
Published: 1 February 2003
... and ubiquitin/proteasome-dependent proteolytic systems are stimulated during moult-induced claw muscle atrophy,when at least 40% of the muscle protein is degraded( Beyette and Mykles, 1999 ;Mykles, 1998 , 1999 ; Skinner, 1966 ). There is a preferential degradation of thin myofilament proteins, resulting...
Journal Articles
J Exp Biol (2002) 205 (15): 2297–2303.
Published: 1 August 2002
...Nicholas J. Hudson; Craig E. Franklin SUMMARY Prolonged muscle disuse in vertebrates can lead to a pathological change resulting in muscle wasting and a loss of muscle strength. In this paper, we review muscle disuse atrophy in the vertebrates and examine the factors that influence the magnitude...
Journal Articles
J Exp Biol (2001) 204 (18): 3201–3208.
Published: 15 September 2001
...Robert H. Fitts; Danny R. Riley; Jeffrey J. Widrick SUMMARY Our purpose is to summarize the major effects of space travel on skeletal muscle with particular emphasis on factors that alter function. The primary deleterious changes are muscle atrophy and the associated decline in peak force and power...