Issues
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Cover image
Cover Image
Cover: In vitro differentiated murine brown adipocytes, stained for lipids (green), F-actin (red) and DNA (blue), are an excellent tool to study the role of adipocytes in energy homeostasis and the endocrine regulation of metabolism. While white adipose tissue is the primary site for storing excess energy, brown adipocytes expend energy through mitochondrial uncoupling. Adipose is organized into individual depots distributed throughout the body, with distinct metabolic and physiological functions. Moreover, individual adipose depots are composed of multiple distinct adipocyte lineages defining their function. Schoettl and colleagues (jeb162958) review the metabolic role of individual adipose depots and the contribution of individual adipocyte lineages. Picture credit: Ruth Karlina and Kenji Schorpp, Helmholtz Zentrum München.
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SPECIAL ISSUE: The biology of fat
INSIDE JEB
EDITORIAL
REVIEWS
Adipogenesis in fish
Summary: This Review focuses on recent discoveries relating to the biology and physiological regulation of adipocyte development in fish.
Are we what we eat? Changes to the feed fatty acid composition of farmed salmon and its effects through the food chain
Summary: This Review describes how dietary fat affects body fat, and how changing diets of farmed fish affect the fillet fatty acids and hence the health benefits for human consumers.
Adipose morphology and metabolic disease
Summary: This Review discusses current literature on adipose morphology, which is defined as the number and size distribution of adipocytes within adipose tissue, and is associated with cardiometabolic disease.
Heterogeneity of adipose tissue in development and metabolic function
Summary: A detailed overview of distinct adipose tissue depots and their differential impact on whole-body physiology and metabolism, describing the complexity of white adipose tissue precursor populations forming adipose tissue depots.
The evolution of body fatness: trading off disease and predation risk
Summary: Body fat is essential to survival – but having too much is detrimental. This paper develops an evolutionary model where disease risk pushes fat storage up while predation risk pushes it down. These patterns result in a system with dual intervention points at low and high levels of adiposity.
The effect of diet and exercise on lipid droplet dynamics in human muscle tissue
Summary: Intramyocellular lipid droplets represent a highly dynamic pool of lipids, which can adjust to alterations in muscle energy supply and demand and can be modulated by both diet and exercise.
Fructose-containing caloric sweeteners as a cause of obesity and metabolic disorders
Summary: Fructose is initially metabolized by fructolysis, gluconeogenesis or lipogenesis in the gut, liver and kidneys, and then made available as lactate, glucose and fatty acids in extrasplanchnic tissues. This two-step metabolism may have important functional consequences for health.
Non-adrenergic control of lipolysis and thermogenesis in adipose tissues
Summary: In this Review, we discuss adrenergic and non-adrenergic mechanisms controlling lipolysis and thermogenesis in adipocytes and provide a comprehensive overview of pro- and anti-lipolytic mediators.
Obese super athletes: fat-fueled migration in birds and bats
Summary: Migratory birds and bats have exceptional abilities to use fat as a fuel for high intensity exercise (flight). This Review examines fat storage and use in these amazing endurance specialists.
The many roles of fats in overwintering insects
Summary: We explore the evidence that insects subsist on fat overwinter, the consequences of subzero temperatures for fat metabolism, and some of the emerging functional roles of fat in overwintering insects.
Adiposity and fat metabolism during combined fasting and lactation in elephant seals
Summary: The northern elephant seal is capable of mobilizing a tremendous amount of lipid very rapidly, and does so during the rare combination of fasting and lactation.
Function and evolution of specialized endogenous lipids in toothed whales
Summary: This article reviews the origins, functions and potential evolution of unusual lipids synthesized by toothed whales in blubber and in the specialized cranial adipose tissues used for echolocation and hearing.
Nature's fat-burning machine: brown adipose tissue in a hibernating mammal
Summary: In this Review, we discuss recent research progress that has identified players and pathways involved in brown adipocyte differentiation and maturation, as well as those involved in metabolic regulation.
Insights into brown adipose tissue evolution and function from non-model organisms
Summary: The diversity of mammalian species from different ecological niches stretches the physiological and molecular scope of brown adipose tissue, thus baring pivotal clues to fully understand the importance of this heater organ.
Genomic imprinting, growth and maternal–fetal interactions
Summary: Imprinted gene products act as fetal and placental endocrine signals during reproduction, as well as directly on maternal tissues to modulate energetic set points that affect nutrient provisioning during pregnancy.
Exercise-induced adaptations to white and brown adipose tissue
Summary: Discussion of studies examining the exercise-induced adaptations to white and brown adipose tissue, and the effects that these exercise-induced adaptations have on overall metabolic health.
Drosophila as a model to study obesity and metabolic disease
Summary: An unrivalled methodological toolbox combined with a complex, evolutionarily conserved physiology uniquely qualifies the fruit fly Drosophila melanogaster as a platform on which to study obesity and obesity-related metabolic disorders.
2023 JEB Outstanding Paper Prize shortlist and winner
The JEB Editors are delighted to announce the shortlisted authors for the 2023 JEB Outstanding Paper Prize. Read the winning paper - Tiny spies: mosquito antennae are sensitive sensors for eavesdropping on frog calls - by Hoover Pantoja-Sanchez and Brian Leavell from Ximena Bernal's lab at Purdue University, USA.
JEB Science Communication Workshop for ECRs
If you’re an early-career researcher interested in science communication and are attending the SEB Annual Conference in Prague this summer, come a day early and join the JEB Editors at a sci comm workshop to learn the key writing skills needed to promote your research to a broad audience beyond your peers (1 July at 14.30-17.30). Places are limited to 24 attendees, and applicants should apply through the SEB registration page by 30 April 2024.
Bridging the gap between controlled conditions and natural habitats in understanding behaviour
Novel technologies enable behavioural experiments with non-model species, in naturalistic habitats and with underexplored behaviours. In their Commentary, Scholz and colleagues discuss how to obtain a deeper understanding of the natural ecology and lifestyle of study animals.
Beluga metabolic measures could help save species
To help save animals from extinction, it’s important to understand what each species needs to survive. This led Jason John et al. to measure the metabolic rates of captive belugas to develop a ‘fish calculator’ showing that the whales need to eat ~23 salmon per day.
ECR Workshop on Positive Peer Review
Are you an ECR looking for tips on how to write concise, astute and useful manuscript reviews? If so, join the JEB Editors at a 2-hour JEB-sponsored Workshop on Positive Peer Review at the Canadian Society of Zoologists annual meeting in Moncton on 9 May 2024 at 13.00-15.00. There are 25 spaces for ECRs and selection is first come, first serve. To sign up, check the ECR Workshop box when you register for the CSZ meeting.