The acute phase response (APR) is a core component of the innate immune response and represents the first line of immune defense used in response to infections. Although several studies with vertebrates reported fever, decrease in food intake and body mass, as well as increase in neutrophil/lymphocyte ratio and total white blood cell count after lipopolysaccharide (LPS) inoculation, there was great variability in the magnitude of these responses. Some of these differences might reflect, to some extent, differences in time of endotoxin inoculation (during activity or resting periods) and dose. Therefore, our study tested the interplay between LPS dose and time of injection on selected physiological (fever and increase in total white blood cell count and neutrophil/lymphocyte ratio), and behavioral (food intake) components of APR using a Neotropical fruit-eating bat (Carollia perspicillata) as a model organism. We predicted that LPS would trigger a dose- and time-dependent response on APR components. APR components were assessed in resting and activity periods after injection of three doses of LPS (5, 10 and 15 mg/kg LPS). The results indicate a more robust decrease in food intake at higher doses during activity period, while increased neutrophil/lymphocyte ratio was more robust during activity period regardless of dose. Furthermore, skin temperature increase lasts longer at higher doses regardless period of injections. Our study offers important insights into the dependence of time as well as the LPS dosage effect in the APR of bats, and how they deal with the magnitude of infections at different time of day.
The acute phase response in bats (Carollia perspicillata) varied with the time and dose of the immune-challenge
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Matheus F. Viola, Luis Gerardo Herrera Montalvo, Ariovaldo P. da Cruz-Neto; The acute phase response in bats (Carollia perspicillata) varied with the time and dose of the immune-challenge. J Exp Biol 2022; jeb.244583. doi: https://doi.org/10.1242/jeb.244583
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