1. Necturus maculosus kidney function has been examined using standard clearance techniques and renal tubular micropuncture methodology. 2. Throughout, cyanocobalamin (vitamin B12) has been used to monitor glomerular filtration rate (GFR) and tubular water movements. It was established that this substance was handled by the Necturus kidney in a similar manner to inulin. It can be readily analysed, together with renal electrolytes, by electron microprobe techniques. 3. Profiles of transtubular gradients (TF:P ratios) along the nephron were established for osmolarity, sodium, potassium, calcium and cobalt (of cyanocobalamin). 4. Ureteral urine is always hyposmotic with respect to plasma and the site of dilution of the plasma ultrafiltrate is within the distal segment. 5. Up to 30% of the filtrate is isosmotically reabsorbed along the proximal tubule; the tubular fluid:plasma ratio for osmolarity and sodium is around 1, and the TF:P for cobalt of cyanocobalamin is about 1.4 by the end of this segment. 6. The renal effects of the neurohypophysial hormone arginine vasotocin (AVT) and an aldosterone antagonist (SC14266; Soldactone) have been examined. 7. AVT was consistently antidiuretic causing both a decreased GFR and an enhanced distal tubular reabsorption of water. 8. SC14266 also increased distal tubular reabsorption of water. Such an effect differs from that found in higher vertebrates, and may indicate a “glucocorticoid-type” of renal action for aldosterone in amphibians.
Micropuncture study of the renal responses of the urodele amphibian Necturus maculosus to injections of arginine vasotocin and an anti-aldosterone compound
H. O. Garland, I. W. Henderson, J. A. Brown; Micropuncture study of the renal responses of the urodele amphibian Necturus maculosus to injections of arginine vasotocin and an anti-aldosterone compound. J Exp Biol 1 August 1975; 63 (1): 249–264. doi: https://doi.org/10.1242/jeb.63.1.249
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New funding schemes for junior faculty staff
In celebration of our 100th anniversary, JEB has launched two new grants to support junior faculty staff working in animal comparative physiology and biomechanics who are within five years of setting up their first lab/research group. Check out our ECR Visiting Fellowships and Research Partnership Kickstart Travel Grants. First deadline for applications is 15 July 2023.
JEB@100: an interview with Monitoring Editor Sanjay Sane
Sanjay Sane tells us about his first experience of publishing with the journal and why he thinks JEB is going to play a key role in our understanding of the current climate crisis and its implications for biodiversity.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Journal of Experimental Biology a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Celebrating 100 years of discovery
This Special Issue focuses on broad biological questions addressed through the lens of comparative biomechanics. Crosscutting through time, this series of Reviews, Commentaries and Research Articles addresses questions from the vantage points of the history of the field, today’s research, and the future of comparative biomechanics. Read the Editorial by Sheila Patek, Monica Daley and Sanjay Sane.
Centenary Review - Adaptive echolocation behavior
Cynthia F. Moss and colleagues Review the behaviours used by echolocating mammals to track and intercept moving prey, interrogate dynamic sonar scenes, and exploit visual and passive acoustic stimuli.
Crucial DNA at crux of insect wing size evolution
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