During its reduction to water, O2 readily gives rise to dangerously reactive intermediates. This threat is diminished by families of defensive enzymes which include the superoxide dismutases, catalases and peroxidases. Free radical chain reactions are controlled by antioxidants, such as ascorbate and the tocopherols, and oxidative damage, which occurs in spite of these defenses, is largely repaired or is nullified by de novo biosynthesis. Yet some damage is sustained and it contributes to mutagenesis, to senescence and to numerous pathological processes.
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REVIEW| 01 April 1998
Oxygen toxicity: a radical explanation.
Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Online Issn: 1477-9145
Print Issn: 0022-0949
J Exp Biol (1998) 201 (8): 1203–1209.
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I Fridovich; Oxygen toxicity: a radical explanation.. J Exp Biol 1 April 1998; 201 (8): 1203–1209. doi: https://doi.org/10.1242/jeb.201.8.1203
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